血清孕激素、糖化血红蛋白和胰岛素水平与妊娠期糖尿病胎膜早破的风险。
Serum progesterone, glycosylated hemoglobin and insulin levels with the risk of premature rupture of membranes in gestational diabetes mellitus.
机构信息
Department of Endocrinology and Metabolism, Affiliated Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China.
Department of Endocrinology, Ezhou Central Hospital, Ezhou City, Hubei Province, China.
出版信息
Clinics (Sao Paulo). 2024 Aug 30;79:100461. doi: 10.1016/j.clinsp.2024.100461. eCollection 2024.
OBJECTIVE
To discuss the correlation between serum progesterone, glycosylated Hemoglobin (HbA1c), and insulin levels in pregnant women with Gestational Diabetes Mellitus (GDM) and the risk of Premature Rupture of Membranes (PROM).
METHODS
A retrospective analysis was conducted on 52 patients diagnosed with GDM who also presented with PROM (Observation group) and compared with 89 patients diagnosed with GDM but not complicated with PROM (Control group). Progesterone, insulin, and HbA1c were detected. Risk factors for PROM in GDM patients were analyzed.
RESULTS
The observation group had higher HbA1c and fasting blood glucose levels. Poor blood glucose control and GWG are risk factors for PROM in GDM patients. PROM increases adverse pregnancy outcomes in GDM. HbA1c, insulin, and HOMA-IR can predict the risk of PROM in GDM.
CONCLUSIONS
The effective prediction of preterm PROM can be achieved through the monitoring of serum HbA1c, insulin levels, and insulin resistance in patients with GDM.
目的
探讨妊娠期糖尿病（GDM）孕妇血清孕激素、糖化血红蛋白（HbA1c）与胰岛素水平与胎膜早破（PROM）风险的相关性。
方法
回顾性分析 52 例 GDM 合并 PROM 患者（观察组），并与 89 例单纯 GDM 患者（对照组）进行比较。检测孕激素、胰岛素、HbA1c。分析 GDM 患者 PROM 的危险因素。
结果
观察组 HbA1c 和空腹血糖水平较高。血糖控制不良和 GWG 是 GDM 患者 PROM 的危险因素。PROM 增加了 GDM 的不良妊娠结局。HbA1c、胰岛素和 HOMA-IR 可预测 GDM 患者 PROM 的风险。
结论
通过监测 GDM 患者血清 HbA1c、胰岛素水平和胰岛素抵抗，可有效预测早产 PROM。
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