Naghipour Bahman, Bagerpour Mahdieh, Shadvar Kamran, Golzari Samad E J, Faridaalaee Gholamreza
Department of Anesthesiology and Intensive Care, Medical Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Gynecology and obestetric, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cardiovasc Thorac Res. 2022;14(1):18-22. doi: 10.34172/jcvtr.2022.05. Epub 2022 Mar 12.
The goal of this study was to elucidate harmful complications of intraoperative hyperglycemia following children cardiac surgery and benefits of insulin administration for accurate blood sugar controlling. this study is a Randomized clinical trial. We conducted this study in the operating room of shahid madani hospital. Fifty patients who were children under 12 years old undergone cardiac surgery using cardiopulmonary bypass (CPB). Intraoperative insulin infusion was administered intravenously targeting blood sugar levels of 110-140 mg/dL. Blood sugar and arterial blood gas (ABG) were measured every 30 min during operation. Inotropes were used less in the study than the placebo group during surgery. The means of hospitalization and extubation time were more in the placebo group than the study group( =0.03) and ( =0.005), respectively. However, the mean time of hospitalization in the ICU ward did not differ significantly between the two groups. Hyperglycemia has a relation with long time of intubation and hospitalization in ICU. These findings suggest the positive effect of accurate blood sugar control on reducing complication and hospitalization time in children undergoing cardiac surgery.
本研究的目的是阐明儿童心脏手术后术中高血糖的有害并发症以及胰岛素给药对精确控制血糖的益处。本研究是一项随机临床试验。我们在沙希德·马达尼医院的手术室进行了这项研究。50例12岁以下接受体外循环心脏手术的儿童患者。术中静脉输注胰岛素,目标血糖水平为110 - 140mg/dL。手术期间每30分钟测量血糖和动脉血气(ABG)。术中研究组使用的血管活性药物比安慰剂组少。安慰剂组的住院时间和拔管时间的均值分别比研究组多(P = 0.03)和(P = 0.005)。然而,两组在重症监护病房(ICU)的平均住院时间没有显著差异。高血糖与ICU长时间插管和住院有关。这些发现表明精确控制血糖对减少儿童心脏手术并发症和住院时间有积极作用。