University Clinic and Outpatient Clinic for Urology, Medical Faculty of Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Coordination Center for Clinical Studies/Trial, University Medicine Halle (Saale), Halle (Saale), Germany.
World J Urol. 2022 Jul;40(7):1769-1775. doi: 10.1007/s00345-022-04036-w. Epub 2022 May 27.
To assess the symptoms, quality of life and sexual well-being in patients with lower urinary tract symptoms due to benign prostatic hyperplasia LUTS/BPH treated with pumpkin seed soft extract (PSE) in routine practice.
This noninterventional study included 130 men treated for up to 24 months. The International Prostate Symptom Score (IPSS) and related quality of life, Aging Males' Symptoms Scale (AMS), and International Index of Erectile Function (IIEF-5) were recorded. Descriptive statistical methods were applied. The mean with 95% confidence interval (CI) was calculated for the primary end point (change in IPSS after 12-month treatment).
Analysis at 12 months included 83 patients [mean (SD) age 65.2 (8.7) years and IPSS (15.6 (3.4), IPSS-QoL 3.4 (0.9)]. AMS and IIEF-5 indicated mild or mild to moderate disorder regarding sexual well-being and erectile dysfunction, respectively. After 12 months, the mean IPSS change from baseline was - 4.7 (95% CI - 5.4 to - 3.9), with 83% (95% CI 65.3 to 84.1) and 53% (95% CI 42.3 to 63.7) of the patients achieving reductions by at least 3 and 5 points, respectively. The proportion of patients with IPSS-QoL below 3 points (mostly satisfied) was 11% (9/83) at baseline and rose to 62% (51/83) and 73% (40/55) at 12 and 24 months, respectively. AMS and IIEF-5 scores did not indicate a negative impact on sexual function during treatment.
In men with a moderate LUTS suggestive of BPH, a low progression risk and an active sex life, treatment with pumpkin seed soft extract provided symptomatic relief, improved IPSS-QoL, and maintained sexual well-being.
DRKS00010729, June 22, 2016.
评估在常规实践中使用南瓜籽油软提取物（PSE）治疗良性前列腺增生（BPH）相关下尿路症状（LUTS/BPH）患者的症状、生活质量和性健康。
本非干预性研究纳入了 130 名接受治疗长达 24 个月的男性患者。记录了国际前列腺症状评分（IPSS）及相关生活质量、男性衰老症状评分（AMS）和国际勃起功能指数（IIEF-5）。应用描述性统计方法。计算了主要终点（治疗 12 个月后 IPSS 的变化）的平均值及 95%置信区间（CI）。
12 个月的分析纳入了 83 名患者[平均（SD）年龄 65.2（8.7）岁和 IPSS（15.6（3.4）），IPSS-QoL 为 3.4（0.9）]。AMS 和 IIEF-5 分别提示与性健康和勃起功能障碍相关的轻度或轻度至中度障碍。治疗 12 个月后，与基线相比，IPSS 的平均变化为-4.7（95%CI-5.4 至-3.9），分别有 83%（95%CI 65.3 至 84.1）和 53%（95%CI 42.3 至 63.7）的患者至少降低了 3 点和 5 点。在基线时，IPSS-QoL 低于 3 分（大多数满意）的患者比例为 11%（9/83），在 12 个月和 24 个月时分别上升至 62%（51/83）和 73%（40/55）。在治疗期间，AMS 和 IIEF-5 评分并未提示对性功能产生负面影响。
在具有中度 LUTS 且提示有 BPH、进展风险低和积极性生活的男性中，使用南瓜籽油软提取物治疗可缓解症状，改善 IPSS-QoL，并维持性健康。
DRKS00010729，2016 年 6 月 22 日。
