Herer B, Brivet F, Fremaux A, Geslin P, Guibert M, Tchernia G, Dormont J
Nouv Rev Fr Hematol (1978). 1986;28(6):371-6.
Asplenic patients are at high risk for the development of fulminant pneumococcal bacteremia. The mortality rate in those infected patients remains high. Therefore pneumococcal polysaccharide vaccine has been recommended, but despite penicillin prophylaxis pneumococcal sepsis can occur in vaccinated patients. We have observed two cases (one fatal) of overwhelming postsplenectomy pneumococcal sepsis in vaccinated patients who received long-term antibiotic prophylaxis. Both exhibited a poor antibody response to polyvalent vaccine.
无脾患者发生暴发性肺炎球菌菌血症的风险很高。这些感染患者的死亡率仍然很高。因此，已推荐接种肺炎球菌多糖疫苗，但尽管进行了青霉素预防，接种疫苗的患者仍可能发生肺炎球菌败血症。我们观察到两例（一例死亡）接受长期抗生素预防的接种疫苗的无脾患者发生了严重的肺炎球菌败血症。两者对多价疫苗的抗体反应均较差。
