体外实验中半乳甘露聚糖硫酸盐和半乳葡甘露聚糖硫酸盐的血液相容性。
Hemocompatibility of Galactomannan and Galactoglucomannan Sulfates in In Vitro Experiments.
机构信息
National Medical Research Center of Hematology, Ministry of Health of the Russian Federation, Moscow, Russia.
Institute of Chemistry and Chemical Technology of the Siberian Division of the Russian Academy of Sciences - Division of Federal Research Center "Krasnoyarsk Scientific Center of the Siberian Division of the Russian Academy of Sciences, Krasnoyarsk, Russia.
出版信息
Bull Exp Biol Med. 2022 May;173(1):98-104. doi: 10.1007/s10517-022-05501-7. Epub 2022 May 27.
We identified compounds that do not independently provoke aggregation of human platelets and do not affect hemolysis of human erythrocytes in vitro: lacking anticoagulant activity sulfated galactoglucomannan (polydispersity 1.43; degree of sulfation 0.66) in concentrations ≤0.2 mg/ml; exhibiting anticoagulant activity (in concentrations up to 0.002 mg/ml) sulfated galactoglucomannan (polydispersity 1.5; degree of sulfation 1.81) and galactomannan obtained by sulfation with the sulfamic acid-urea complex (polydispersity 2.75; degree of sulfation 1.25) and galactomannans obtained by sulfation with chlorosulfonic acid in 1,4-dioxane (polydispersity 1.61/22.27; degree of sulfation 1.00/0.74).
我们鉴定出一些化合物，它们不会单独引起人血小板聚集，也不会影响人红细胞在体外的溶血：在浓度≤0.2mg/ml 时，缺乏抗凝活性的硫酸半乳糖葡甘露聚糖（多分散性 1.43；硫酸化度 0.66）；在浓度高达 0.002mg/ml 时，具有抗凝活性的硫酸半乳糖葡甘露聚糖（多分散性 1.5；硫酸化度 1.81）和硫酸氨基脲复合物硫酸化得到的半乳甘露聚糖（多分散性 2.75；硫酸化度 1.25）以及在 1,4-二恶烷中用氯磺酸硫酸化得到的半乳甘露聚糖（多分散性 1.61/22.27；硫酸化度 1.00/0.74）。
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