人PRMT5使OCTR-1和人α-2A肾上腺素能受体在第三个细胞内环内发生甲基化。
The OCTR-1 and Human Alpha-2A Adrenergic Receptors are Methylated within the Third Intracellular Loop by Human PRMT5 .
作者信息
Bowitch Alexander, Chinsky Tyler M, Yu Michael C, Ferkey Denise M
机构信息
Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260 USA.
出版信息
MicroPubl Biol. 2022 Mar 23;2022. doi: 10.17912/micropub.biology.000546. eCollection 2022.
Abstract
Arginines within the third intracellular loop of the OCTR-1 and human ADRA2A receptors are methylated by the human protein arginine methyltransferase PRMT5 . Methylation of these residues could serve to modulate receptor signaling .
摘要
人OCTR-1和人ADRA2A受体第三个细胞内环中的精氨酸被人蛋白质精氨酸甲基转移酶PRMT5甲基化。这些残基的甲基化可能有助于调节受体信号传导。
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