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人PRMT5使OCTR-1和人α-2A肾上腺素能受体在第三个细胞内环内发生甲基化。

The OCTR-1 and Human Alpha-2A Adrenergic Receptors are Methylated within the Third Intracellular Loop by Human PRMT5 .

作者信息

Bowitch Alexander, Chinsky Tyler M, Yu Michael C, Ferkey Denise M

机构信息

Department of Biological Sciences, University at Buffalo, The State University of New York, Buffalo, NY 14260 USA.

出版信息

MicroPubl Biol. 2022 Mar 23;2022. doi: 10.17912/micropub.biology.000546. eCollection 2022.

DOI:10.17912/micropub.biology.000546
PMID:35622502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9007614/
Abstract

Arginines within the third intracellular loop of the OCTR-1 and human ADRA2A receptors are methylated by the human protein arginine methyltransferase PRMT5 . Methylation of these residues could serve to modulate receptor signaling .

摘要

人OCTR-1和人ADRA2A受体第三个细胞内环中的精氨酸被人蛋白质精氨酸甲基转移酶PRMT5甲基化。这些残基的甲基化可能有助于调节受体信号传导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5d/9007614/985f65968472/25789430-2022-micropub.biology.000546.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5d/9007614/985f65968472/25789430-2022-micropub.biology.000546.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc5d/9007614/985f65968472/25789430-2022-micropub.biology.000546.jpg

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本文引用的文献

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Methylation of the D2 dopamine receptor affects binding with the human regulatory proteins Par-4 and Calmodulin.D2多巴胺受体的甲基化会影响其与人类调节蛋白Par-4和钙调蛋白的结合。
MicroPubl Biol. 2021 Feb 9;2021. doi: 10.17912/micropub.biology.000366.
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The Protein Arginine Methyltransferase PRMT-5 Regulates SER-2 Tyramine Receptor-Mediated Behaviors in .蛋白质精氨酸甲基转移酶PRMT-5调节秀丽隐杆线虫中SER-2酪胺受体介导的行为 。 （注：原文中“. ”处似乎信息不完整，推测补充了“秀丽隐杆线虫”以使句子完整通顺）
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G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?
G 蛋白偶联受体作为已批准药物的靶点：有多少个靶点和多少种药物？
Mol Pharmacol. 2018 Apr;93(4):251-258. doi: 10.1124/mol.117.111062. Epub 2018 Jan 3.
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G protein-coupled receptor kinases: Past, present and future.G 蛋白偶联受体激酶：过去、现在和未来。
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The protein arginine methyltransferase PRMT5 promotes D2-like dopamine receptor signaling.蛋白质精氨酸甲基转移酶PRMT5促进D2样多巴胺受体信号传导。
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Mutant G-protein-coupled receptors as a cause of human diseases.突变型G蛋白偶联受体作为人类疾病的一个病因
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