用格氏试剂对甲苯磺酰化腺苷衍生物进行脱氧反应。
The deoxygenations of tosylated adenosine derivatives with Grignard reagents.
作者信息
Kawana M, Takeuchi K, Ohba T, Kuzuhara H
出版信息
Nucleic Acids Symp Ser. 1986(17):37-40.
PMID:3562272
Abstract
The reactions of 2'-O- or 3'-O-tosylated adenosines with Grignard reagents resulted in the formation of various products, which were deoxy or branched-chain deoxy sugar nucleosides, 1',2'-unsaturated nucleosides, 3'-deoxy-2'-keto sugar nucleosides, and so on. The convenient method for the synthesis of the 3'-deoxy-2'-keto adenine nucleoside is described.
摘要
2'-O-或3'-O-甲苯磺酰化腺苷与格氏试剂反应生成了各种产物，包括脱氧或支链脱氧糖核苷、1',2'-不饱和核苷、3'-脱氧-2'-酮糖核苷等。本文描述了合成3'-脱氧-2'-酮腺嘌呤核苷的简便方法。
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