磷脂酶D催化的转磷脂酰基反应合成5'-磷脂酰核苷
Synthesis of 5'-phosphatidylnucleosides by phospholipase D-catalyzed transphosphatidylation.
作者信息
Shuto S, Ueda S, Itoh H, Endo E, Fukukawa K, Imamura S, Tsujino M, Matsuda A, Ueda T
出版信息
Nucleic Acids Symp Ser. 1986(17):73-6.
PMID:3562280
Abstract
Phospholipase D from Streptomyces effectively catalyzed the transfer reaction of the phosphatidyl residue from phosphatidylcholine to the 5'-hydroxyl group of nucleosides. A variety of 5'-phosphatidylnucleosides were prepared by this reaction in high yields. Some of them showed marked antitumor activities in mice.
摘要
来自链霉菌的磷脂酶D有效地催化了磷脂酰残基从磷脂酰胆碱向核苷5'-羟基的转移反应。通过该反应以高产率制备了多种5'-磷脂酰核苷。其中一些在小鼠中显示出显著的抗肿瘤活性。
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