Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
Department of Biology, Stanford University, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Immunity. 2022 Jun 14;55(6):925-944. doi: 10.1016/j.immuni.2022.05.005. Epub 2022 May 13.
Neutralizing antibodies can block infection, clear pathogens, and are essential to provide long-term immunity. Since the onset of the pandemic, SARS-CoV-2 neutralizing antibodies have been comprehensively investigated and critical information on their development, function, and potential use to prevent and treat COVID-19 have been revealed. With the emergence of SARS-CoV-2 immune escape variants, humoral immunity is being challenged, and a detailed understanding of neutralizing antibodies is essential to guide vaccine design strategies as well as antibody-mediated therapies. In this review, we summarize some of the key findings on SARS-CoV-2 neutralizing antibodies, with a focus on their clinical application.
中和抗体可以阻止感染、清除病原体，是提供长期免疫力的关键。自大流行开始以来，人们对 SARS-CoV-2 中和抗体进行了全面研究，揭示了其发展、功能和潜在用途的关键信息，以预防和治疗 COVID-19。随着 SARS-CoV-2 免疫逃逸变体的出现，体液免疫受到了挑战，深入了解中和抗体对于指导疫苗设计策略以及抗体介导的治疗至关重要。在这篇综述中，我们总结了一些关于 SARS-CoV-2 中和抗体的关键发现，重点介绍了它们的临床应用。
