Molecular mechanism of the ESRRG-PERM1-CKMT2 signal axis in ovariectomized female rats with OSAHS.

This study aims to investigate the role of ESRRG-PERM1-CKMT2 signal axis, estrogen and genioglossal muscle contractile times in the development of Obstructive sleep apnea-hypopnea syndrome (OSAHS). This is a randomized controlled trial, and a total of 48 female rats are included and divided into following four groups: control group, sham operation group, model group and treatment group. A OSAHS rat model is established and then ESRRG, PERM1 and CKMT2 protein are detected by western blotting. Genioglossal muscle contractile times and estrogen level are also by detected. Our outcomes show that the level of ESRRG, PERM1, CKMT2 protein in control group, sham operation group, and treatment group are significantly up-regulated compared with that in model group. Genioglossal muscle contractile times and estrogen level in control group, sham operation group, and treatment group are also remarkably higher than those in model group. In addition, compared to the number of OSAHS in model group, the number of OSAHS in control group, sham operation group and treatment group is obviously decreased. We can conclude that up-regulated of ESRRG, PERM1, CKMT2 and estrogen can prevent or inhibit the development of OSAHS.