School of Kinesiology and Health Studies, Queen's University, Kingston, ON K7L3N6, Canada.
Department of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
Genes (Basel). 2024 Oct 9;15(10):1305. doi: 10.3390/genes15101305.
BACKGROUND/OBJECTIVES: This systematic review aims to explore the role of PERM1 across different organisms, tissues, and cellular functions, with a particular focus on its involvement in regulating skeletal muscle mitochondrial biogenesis.
This systematic review follows The PRISMA 2020 Statement. We used the Covidence systematic review software for abstract/title screening, full-text review, and data extraction. The review included studies that examined PERM1 expression or activity in skeletal muscle, heart, and adipose tissue and/or cells, from mice, rats, and humans, and involved exercise or disease models. Risk of bias was assessed using the Cochrane Collaboration tool, and the data were extracted and synthesized qualitatively, with bioinformatic analyses performed using the MetaMEx database.
Twenty-one studies were included in our data extraction process, where 10 studies involved humans, 21 involved mice, four involved rats, and 11 involved cells.
PERM1 in skeletal muscle increases with endurance exercise, affecting muscle function and oxidative metabolism, but its role in humans is not well understood. In cardiac tissue, PERM1 is vital for function and mitochondrial biogenesis purposes, but decreases with disease and pressure overload. Our review synthesizes the current understanding of PERM1's function, raises awareness of its role in mitochondrial regulation, and identifies key areas for future research in the field.
背景/目的：本系统评价旨在探讨 PERM1 在不同生物体、组织和细胞功能中的作用，特别关注其在调节骨骼肌线粒体生物发生中的作用。
本系统评价遵循 PRISMA 2020 声明。我们使用 Covidence 系统评价软件进行摘要/标题筛选、全文审查和数据提取。该综述包括研究 PERM1 在骨骼肌、心脏和脂肪组织和/或细胞中的表达或活性的研究，涉及来自小鼠、大鼠和人类的运动或疾病模型。使用 Cochrane 协作工具评估偏倚风险，并对数据进行定性提取和综合，使用 MetaMEx 数据库进行生物信息学分析。
我们的数据提取过程中包括 21 项研究，其中 10 项涉及人类，21 项涉及小鼠，4 项涉及大鼠，11 项涉及细胞。
骨骼肌中的 PERM1 随着耐力运动而增加，影响肌肉功能和氧化代谢，但在人类中的作用尚未得到很好的理解。在心脏组织中，PERM1 对功能和线粒体生物发生至关重要，但随着疾病和压力超负荷而减少。我们的综述综合了目前对 PERM1 功能的理解，提高了对其在调节线粒体方面作用的认识，并确定了该领域未来研究的关键领域。
