Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Nutr ESPEN. 2022 Jun;49:53-60. doi: 10.1016/j.clnesp.2022.03.043. Epub 2022 Apr 14.
BACKGROUND & AIMS: In the current study, we aimed to assess the effect of dried Ziziphus jujube on blood glucose, lipid profiles, anthropometric indices, and inflammatory factors in type 2 diabetic(T2D) patients.
In this randomized controlled clinical trial, 48 patients, aged 30-65 years, were randomly assigned to two intervention(n = 24) and control(n = 24) groups. The subjects in the intervention group received 30 g Ziziphus jujube daily for 12 weeks. At baseline and the end of the 12th week, 10 ml of blood was taken from each patient after a 12- to 14-h overnight fasting. Plasma levels of fasting plasma glucose (FPG), triglycerides(TGs), total cholesterol(TC), high-density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDL-C), high-sensitivity C-reactive protein(hs-CRP), and interleukin-6(IL-6) were measured. Anthropometric indices were determined.
Plasma FPG, TG, TC, and LDL-C decreased significantly up to -11.36%, -13.59%, -7.46%, -7.65% in the Ziziphus jujube group at the end of week 12 compared to baseline, respectively (P < 0.05), and this reduction was significant in comparison with the control group (P < 0.05). The plasma hs-CRP reduced significantly up to -24.46% in the Ziziphus jujube group at the end of week 12 compared to baseline (P < 0.05), however, this reduction was not significant in comparison with the control group (P < 0.05). Also, there were no significant differences between the two groups in mean changes of body mass index, plasma HDL-C, and IL-6.
The current study showed that daily consumption of Ziziphus jujube may have beneficial effects on the lipid profiles and blood glucose levels in T2D.
T his clinical trial was registered at the Iranian registry of clinical trials (IRCT registration number: IRCT20181210041913N1).
在本研究中，我们旨在评估酸枣对 2 型糖尿病（T2D）患者血糖、血脂谱、人体测量指数和炎症因子的影响。
在这项随机对照临床试验中，将 48 名年龄在 30-65 岁的患者随机分为两组，每组 24 人。干预组每天服用 30 克酸枣，共 12 周。在基线和第 12 周结束时，每位患者在禁食 12-14 小时后抽取 10ml 血液。测量空腹血浆葡萄糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、高敏 C 反应蛋白（hs-CRP）和白细胞介素-6（IL-6）的血浆水平。测量人体测量指数。
与基线相比，酸枣组在第 12 周末 FPG、TG、TC 和 LDL-C 分别下降了-11.36%、-13.59%、-7.46%和-7.65%（P<0.05），与对照组相比，这一降幅有显著差异（P<0.05）。与基线相比，酸枣组在第 12 周末 hs-CRP 显著下降了-24.46%（P<0.05），但与对照组相比，这一降幅无显著差异（P<0.05）。两组间体重指数、血浆 HDL-C 和 IL-6 的平均变化无显著差异。
本研究表明，每天食用酸枣可能对 T2D 患者的血脂谱和血糖水平有有益影响。
本临床试验在伊朗临床试验注册中心（IRCT 注册号：IRCT20181210041913N1）注册。
