Mohamed M K, Burbacher T M, Mottet N K
Pharmacol Toxicol. 1987 Jan;60(1):29-36. doi: 10.1111/j.1600-0773.1987.tb01715.x.
These studies were performed to investigate the effects of MeHg on testicular function in Macaca fascicularis monkeys. In an in vivo study involving oral treatment of adult males Macaca fascicularis monkeys with MeHg for 20 weeks, changes in spermatozoal production, motility and morphology and in serum testosterone were followed before, during and after treatment. MeHg treatment significantly decreased % motile spermatozoa and scores for sperm speed and forward progression and increased % abnormal sperm tail forms, at sub-neurotoxic levels. The MeHg-induced increase in semen abnormalities was not accompanied by any significant changes in serum levels of testosterone. No consistent histological abnormalities were detected in testicular biopsies from the treated animals at the end of the treatment period. A good recovery pattern was observed for the MeHg effects on sperm motility while this was unclear for the effects on sperm morphology.
进行这些研究是为了调查甲基汞对食蟹猴睾丸功能的影响。在一项体内研究中，成年雄性食蟹猴经口给予甲基汞治疗20周，在治疗前、治疗期间和治疗后跟踪精子生成、活力和形态以及血清睾酮的变化。在亚神经毒性水平下，甲基汞治疗显著降低了活动精子的百分比、精子速度和向前运动评分，并增加了异常精子尾部形态的百分比。甲基汞诱导的精液异常增加并未伴有血清睾酮水平的任何显著变化。在治疗期结束时，未在接受治疗动物的睾丸活检中检测到一致的组织学异常。观察到甲基汞对精子活力的影响有良好的恢复模式，而对精子形态的影响尚不清楚。
