Department of Nutrition and Health, Universidade Federal de Viçosa - UFV, Viçosa, Minas Gerais, Brazil.
Department of Nutrition and Health, Universidade Federal de Viçosa - UFV, Viçosa, Minas Gerais, Brazil.
Clin Nutr ESPEN. 2022 Jun;49:86-91. doi: 10.1016/j.clnesp.2022.02.121. Epub 2022 Mar 9.
To investigate if the gout-protective effect of low-fat dairy products could be attributed to the urate-lowering effect of calcium.
This is a placebo-controlled trial in which thirty-five adult (aged 18-42 years) female low-calcium consumers (<800 mg/d) were randomized to one of three treatment groups: low calcium breakfast (control, ∼70 mg of calcium/d) -C or high-calcium breakfast (∼770 mg/d) from calcium citrate - CIT or from skim milk - SM, during 45 consecutive days. Breakfasts were matched for potential confounders and were provided as part of an energy-restricted normoprotein diet containing an additional 800 mg of calcium/d. Dual-energy X-ray absorptiometry measurements (body fat assessment) and fasting blood samples (urate, ionic calcium, PTH, and 1,25-(OH)2-D3) were taken at baseline and the end of the experiment.
http://www.ensaiosclinicos.gov.br/ (RBR-7Q2N33).
Despite no significant changes in total body weight/fat, CIT and SM led to a significant reduction in serum urate and ionic calcium, but did not affect PTH and vitamin D concentrations compared to C. CIT and SM reduced baseline serum urate by ∼14% and ∼17%, respectively. There was a trend to a positive correlation between changes in serum urate and changes in ionic calcium on day 45 (r = 0.327, P = 0.055).
Calcium supplementation (770 mg/d from dairy or calcium citrate) reduced serum urate concentrations, suggesting that the gout-protective effect of low-fat dairy consumption is at least partly due to a urate-lowering effect of calcium.
研究低脂乳制品的降尿酸作用是否归因于钙的降尿酸作用。
这是一项安慰剂对照试验，将 35 名成年（18-42 岁）低钙摄入者（<800mg/d）随机分为三组：低钙早餐（对照组，约 70mg/d 钙）-C 或高钙早餐（约 770mg/d），来自柠檬酸钙 - CIT 或脱脂牛奶 - SM，连续 45 天。早餐根据潜在的混杂因素进行匹配，并作为能量限制的正常蛋白饮食的一部分提供，该饮食额外含有 800mg/d 的钙。在基线和实验结束时进行双能 X 射线吸收法测量（体脂评估）和空腹血样采集（尿酸、离子钙、PTH 和 1,25-(OH)2-D3）。
http://www.ensaiosclinicos.gov.br/（RBR-7Q2N33）。
尽管总体重/脂肪没有明显变化，但 CIT 和 SM 导致血清尿酸和离子钙显著降低，但与 C 相比，不影响 PTH 和维生素 D 浓度。CIT 和 SM 分别使基线血清尿酸降低了约 14%和 17%。第 45 天，血清尿酸变化与离子钙变化之间存在正相关趋势（r=0.327，P=0.055）。
钙补充剂（770mg/d 来自乳制品或柠檬酸钙）降低了血清尿酸浓度，表明低脂乳制品摄入的降尿酸作用至少部分归因于钙的降尿酸作用。
