Ibrahim A
J Urol. 1979 May;121(5):572-4. doi: 10.1016/s0022-5347(17)56885-8.
This prospective study confirms the previously reported high incidence of uric acid lithiasis in the Sudan. Despite this fact urinary pH in patients in whom stones formed was not significantly different from controls (p greater than 0.05). However, a significantly high serum uric acid level (p less than 0.01) was associated with recurrent and/or bilateral stones. In patients with single episodes of stones significant hyponatremia (p less than 0.001) may indicate excessive sweating. The resulting low urine output supersaturated with crystals may explain lithogenesis in this group of patients.
这项前瞻性研究证实了苏丹此前报道的高尿酸结石发病率。尽管如此，结石形成患者的尿液pH值与对照组并无显著差异（p大于0.05）。然而，血清尿酸水平显著升高（p小于0.01）与复发性和/或双侧结石相关。在单发结石患者中，显著低钠血症（p小于0.001）可能表明出汗过多。由此导致的尿量减少并伴有晶体过饱和，可能解释了该组患者的结石形成。
