转录保留 5-羟色胺能连接可能有助于神经退行性变。
Transcriptional preservation of serotonergic connectivity may shed light on neurodegeneration.
机构信息
Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), CONICET, Universidad de Buenos Aires, Buenos Aires, Argentina.
出版信息
Trends Neurosci. 2022 Aug;45(8):563-565. doi: 10.1016/j.tins.2022.05.004. Epub 2022 May 24.
PMID:35624030
Abstract
In a recent study, Kitt, Tabuchi, and colleagues unveiled a novel function of an early-stage transcriptional network to maintain the adult integrity of serotonergic connectivity. Reported axonal and synaptic morphological alterations in serotonin (5-HT) neurons after selective inactivation of Lmx1b/Pet1 transcriptional networks may help to understand aging and neurodegenerative processes.
摘要
在最近的一项研究中，Kitt、Tabuchi 和同事揭示了早期转录网络的一个新功能，即维持血清素能连接的成年完整性。选择性失活 Lmx1b/Pet1 转录网络后血清素（5-HT）神经元的轴突和突触形态改变，可能有助于理解衰老和神经退行性过程。
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