Collodel Giulia, Moretti Elena, Noto Daria, Corsaro Roberta, Signorini Cinzia
Department of Molecular and Developmental Medicine, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 16, 53100 Siena, Italy.
Antioxidants (Basel). 2022 May 19;11(5):1002. doi: 10.3390/antiox11051002.
In this review, the role of fatty acids (FA) in human pathological conditions, infertility in particular, was considered. FA and FA-derived metabolites modulate cell membrane composition, membrane lipid microdomains and cell signaling. Moreover, such molecules are involved in cell death, immunological responses and inflammatory processes. Human health and several pathological conditions are specifically associated with both dietary and cell membrane lipid profiles. The role of FA metabolism in human sperm and spermatogenesis has recently been investigated. Cumulative findings indicate F isoprostanes (oxygenated products from arachidonic acid metabolism) and resolvins (lipid mediators of resolution of inflammation) as promising biomarkers for the evaluation of semen and follicular fluid quality. Advanced knowledge in this field could lead to new scenarios in the treatment of infertility.
在本综述中，探讨了脂肪酸（FA）在人类病理状况，尤其是不孕症中的作用。脂肪酸及其衍生代谢物可调节细胞膜组成、膜脂微区和细胞信号传导。此外，这些分子还参与细胞死亡、免疫反应和炎症过程。人类健康和一些病理状况与饮食及细胞膜脂质谱密切相关。最近对脂肪酸代谢在人类精子和精子发生中的作用进行了研究。累积研究结果表明，F异前列腺素（花生四烯酸代谢的氧化产物）和消退素（炎症消退的脂质介质）有望成为评估精液和卵泡液质量的生物标志物。该领域的前沿知识可能会为不孕症的治疗带来新的前景。
