Flores-López María, García-Marchena Nuria, Araos Pedro, Requena-Ocaña Nerea, Porras-Perales Oscar, Torres-Galván Sandra, Suarez Juan, Pizarro Nieves, de la Torre Rafael, Rubio Gabriel, Ruiz-Ruiz Juan Jesús, Rodríguez de Fonseca Fernando, Serrano Antonia, Pavón-Morón Francisco Javier
Instituto de Investigación Biomédica de Málaga-IBIMA, 29590 Málaga, Spain.
Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, 29010 Málaga, Spain.
Brain Sci. 2022 Apr 30;12(5):588. doi: 10.3390/brainsci12050588.
Preclinical evidence suggests a main role of lysophosphatidic acid (LPA) signaling in drug addiction. Recently, we reported alterations in the plasma concentrations of LPA species in patients with alcohol use disorder (AUD). As there are sex differences in drug addiction, the main aim of the present study was to investigate whether relevant LPA species (16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA) were associated with sex and/or substance use disorder (SUD). This exploratory study was conducted in 214 abstinent patients with lifetime SUD, and 91 healthy control subjects. The SUD group was divided according to the diagnosis of AUD and/or cocaine use disorder (CUD). Participants were clinically assessed, and plasma samples were collected to determine LPA species and total LPA. We found that LPA concentrations were significantly affected by sex, and women showed higher concentrations than men. In addition, there were significantly lower 16:0-LPA, 18:2-LPA and total LPA concentrations in patients with SUD than in controls. Namely, patients with CUD and AUD + CUD showed lower LPA concentrations than controls or patients with AUD. In conclusion, our data suggest that LPA species could be potential biomarkers for SUD in women and men, which could contribute to a better stratification of these patients in treatment programs.
临床前证据表明溶血磷脂酸（LPA）信号在药物成瘾中起主要作用。最近，我们报道了酒精使用障碍（AUD）患者血浆中LPA种类的浓度变化。由于药物成瘾存在性别差异，本研究的主要目的是调查相关LPA种类（16:0-LPA、18:0-LPA、18:1-LPA、18:2-LPA和20:4-LPA）是否与性别和/或物质使用障碍（SUD）相关。这项探索性研究纳入了214名有终生SUD的戒断患者和91名健康对照者。SUD组根据AUD和/或可卡因使用障碍（CUD）的诊断进行划分。对参与者进行临床评估，并采集血浆样本以测定LPA种类和总LPA。我们发现LPA浓度受性别显著影响，女性的浓度高于男性。此外，SUD患者的16:0-LPA、18:2-LPA和总LPA浓度显著低于对照组。具体而言，CUD患者以及AUD + CUD患者的LPA浓度低于对照组或AUD患者。总之，我们的数据表明LPA种类可能是男性和女性SUD的潜在生物标志物，这有助于在治疗方案中对这些患者进行更好的分层。
