Sammarra Ilaria, Bennardo Luigi, Provenzano Eugenio, Patruno Cataldo, Nisticò Steven Paul
Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Department of Health Sciences, Magna Graecia University, 88100 Catanzaro, Italy.
Brain Sci. 2022 May 5;12(5):605. doi: 10.3390/brainsci12050605.
Prurigo nodularis (PN) is a dermatological condition characterized by nodular hyperkeratotic lesions mainly on the legs and arms. Asymmetrical PN is a rare dermatological condition often associated with paralysis and stroke. In this paper, we present the case of a 77-year-old woman who developed post-ictal PN which responded to dupilumab, an anti-interleukin-4/13 drug approved for the management of AD, with an extreme reduction in itch sensation. Dupilumab and other therapies reducing Th2 inflammation may, in the future, become an alternative treatment for post-ictal pruritus/PN nonresponding to traditional therapies. Of course, larger studies will be necessary to confirm our case's findings.
结节性痒疹（PN）是一种皮肤病，其特征是主要出现在腿部和手臂的结节性角化过度病变。不对称性PN是一种罕见的皮肤病，常与瘫痪和中风相关。在本文中，我们报告了一例77岁女性患者，她在癫痫发作后出现了PN，对度普利尤单抗（一种被批准用于治疗特应性皮炎的抗白细胞介素-4/13药物）有反应，瘙痒感极度减轻。度普利尤单抗和其他减少Th2炎症的疗法未来可能成为对传统疗法无反应的癫痫后瘙痒/PN的替代治疗方法。当然，需要更大规模的研究来证实我们病例的发现。
