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剖宫产术后患者的抗生素使用情况:贝宁的一项三级研究

Antibiotic Usage in Patients Having Undergone Caesarean Section: A Three-Level Study in Benin.

作者信息

Dohou Angèle Modupè, Buda Valentina Oana, Yemoa Loconon Achille, Anagonou Severin, Van Bambeke Françoise, Van Hees Thierry, Dossou Francis Moïse, Dalleur Olivia

机构信息

Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Emmanuel Mounier 73, 1200 Brussels, Belgium.

Faculté des Sciences de la Santé, Université d'Abomey Calavi, Cotonou 01 BP 188, Benin.

出版信息

Antibiotics (Basel). 2022 May 4;11(5):617. doi: 10.3390/antibiotics11050617.

Abstract

The intense use and misuse of antibiotics is undoubtedly the main factor associated with the high numbers of antibiotic-resistant pathogenic and commensal bacteria worldwide. In low-income countries, this misuse and overuse is widespread, with great consequences at the personal and global levels. In the context of user fee exemptions in caesarean sections, we performed a descriptive study in women to assess the use of antibiotics on three levels-antenatal, during caesarean section, and postpartum-in four Beninese hospitals. Out of the 141 women included, 56.7% were using antibiotics. More than the half (71.3%) were taking more than one antibiotic, either for a long time or in acute treatment. In prophylaxis, the timing, dose, and duration of administration were not correctly achieved. Only 31.2% of women received optimal antibiotic prophylaxis. Various antibiotics including broad-spectrum molecules were used in the patients after caesarean section. The use of antibiotics was improper on the three levels studied. The high rate of self-administered antibiotics, the poor achievement of antibiotic prophylaxis, and the postpartum overuse of antibiotics showed a poor quality of care provided in pregnancy. A national policy is essential to improve the use of antibiotics by the general public as well as by professionals.

摘要

抗生素的大量使用和滥用无疑是全球抗生素耐药性致病和共生细菌数量众多的主要相关因素。在低收入国家,这种滥用和过度使用现象普遍存在,在个人和全球层面都造成了严重后果。在剖宫产手术免费用药的背景下,我们对贝宁四家医院的女性进行了一项描述性研究,以评估抗生素在产前、剖宫产手术期间和产后三个阶段的使用情况。在纳入研究的141名女性中,56.7%正在使用抗生素。超过半数(71.3%)的女性长期或在急性治疗中使用不止一种抗生素。在预防性用药方面,给药时间、剂量和持续时间均未正确把握。只有31.2%的女性接受了最佳抗生素预防性用药。剖宫产术后患者使用了包括广谱分子在内的各种抗生素。在所研究的三个阶段,抗生素的使用均不恰当。自行使用抗生素的比例很高、抗生素预防性用药效果不佳以及产后抗生素过度使用表明孕期提供的护理质量较差。制定一项国家政策对于改善公众以及专业人员对抗生素的使用至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dea5/9137971/88c91c2a985f/antibiotics-11-00617-g001.jpg

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