Pedersen T K, Blaakaer J
Gynaekologisk-obstetrisk afdeling, Sønderborg Sygehus.
Ugeskr Laeger. 1997 Feb 24;159(9):1265-7.
We investigated the guidelines for patient selection and drug regimens for use of antibiotic prophylaxis in relation to Caesarean section in the maternity clinics in Denmark. A questionnaire was sent to all the Danish maternity clinics that perform Caesarean section, concerning indications for use of antibiotic prophylaxis and antibiotic regimens to patients undergoing acute and elective Caesarean section. All departments (n = 48) returned the questionnaire. Twenty departments (46%) provided written guidelines for antibiotic prophylaxis. Four departments (8%) used antibiotic prophylaxis in elective Caesarean sections, 25 departments (52%) used antibiotics in all emergency sections. In the presence of rupture of the membranes or prolongation of labour (> 12 hrs) 58 and 63% of the departments used antibiotic prophylaxis, respectively. The most frequent first choice drug was cefuroxim, employed by 27 departments (56%). Concerning timing, 21 departments (44%) gave antibiotics after cord clamping and 13 departments (27%) before incision. We propose a nation-wide prospective investigation on the rate of infections associated with Caesarean section to set up rational guidelines for antibiotic prophylaxis.
我们调查了丹麦产科诊所剖宫产抗生素预防使用的患者选择指南和药物方案。向所有进行剖宫产的丹麦产科诊所发送了一份问卷，内容涉及急性和择期剖宫产患者抗生素预防的使用指征和抗生素方案。所有科室（n = 48）都返回了问卷。20个科室（46%）提供了抗生素预防的书面指南。4个科室（8%）在择期剖宫产中使用抗生素预防，25个科室（52%）在所有急诊剖宫产中使用抗生素。在胎膜破裂或产程延长（> 12小时）的情况下，分别有58%和63%的科室使用抗生素预防。最常用的首选药物是头孢呋辛，27个科室（56%）使用。关于给药时间，21个科室（44%）在脐带结扎后给予抗生素，13个科室（27%）在切开前给予。我们建议在全国范围内对剖宫产相关感染率进行前瞻性调查，以制定合理的抗生素预防指南。
