Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65212, USA.
Harry S. Truman Veterans Hospital, Columbia, MO 65201, USA.
Biomolecules. 2022 Apr 27;12(5):645. doi: 10.3390/biom12050645.
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. HCC is diagnosed in its advanced stage when limited treatment options are available. Substantial morphologic, genetic and epigenetic heterogeneity has been reported in HCC, which poses a challenge for the development of a targeted therapy. In this review, we discuss the role and involvement of several microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma with a special emphasis on their possible role as a diagnostic and prognostic tool in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
肝细胞癌 (HCC) 是全球癌症相关死亡的第二大主要原因。当治疗选择有限时，HCC 被诊断为晚期。HCC 存在大量的形态、遗传和表观遗传异质性，这给靶向治疗的发展带来了挑战。在这篇综述中，我们讨论了几种 microRNAs (miRs) 在肝细胞癌异质性和转移中的作用和参与，特别强调了它们作为诊断和预后工具在肝细胞癌风险预测、早期检测和治疗中的可能作用。
