Ogata Kenichi, Moriyama Masafumi, Matsumura-Kawashima Mayu, Kawado Tatsuya, Yano Aiko, Nakamura Seiji
Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Biomedicines. 2022 May 2;10(5):1049. doi: 10.3390/biomedicines10051049.
An alternative source of mesenchymal stem cells has recently been discovered: dental pulp stem cells (DPSCs), including deciduous teeth, which can thus comprise potential tools for regenerative medicine. DPSCs derive from the neural crest and are normally implicated in dentin homeostasis. The clinical application of mesenchymal stem cells (MSCs) involving DPSCs contains various limitations, such as high cost, low safety, and cell handling issues, as well as invasive sample collection procedures. Although MSCs implantation offers favorable outcomes on specific diseases, implanted MSCs cannot survive for a long period. It is thus considered that their mediated mechanism of action involves paracrine effects. It has been recently reported that secreted molecules in DPSCs-conditioned media (DPSC-CM) contain various trophic factors and cytokines and that DPSC-CM are effective in models of various diseases. In the current study, we focus on the characteristics of DPSC-CM and their therapeutic potential against various disorders.
牙髓干细胞（DPSCs），包括乳牙牙髓干细胞，因此它们可能成为再生医学的潜在工具。DPSCs起源于神经嵴，通常参与牙本质内稳态。涉及DPSCs的间充质干细胞（MSCs）的临床应用存在各种局限性，如成本高、安全性低、细胞处理问题以及侵入性样本采集程序。尽管MSCs植入对特定疾病有良好效果，但植入的MSCs不能长期存活。因此认为它们的作用介导机制涉及旁分泌效应。最近有报道称，DPSCs条件培养基（DPSC-CM）中的分泌分子含有多种营养因子和细胞因子，并且DPSC-CM在各种疾病模型中都有效。在本研究中，我们重点关注DPSC-CM的特性及其对各种疾病的治疗潜力。
