Kuetting Daniel, Kupczyk Patrick, Dell Tatjana, Luetkens Julian A, Meyer Carsten, Attenberger Ulrike I, Pieper Claus C
Department of Diagnostic and Interventional Radiology, University of Bonn, Venusberg-Campus 1, 53105 Bonn, Germany.
Biomedicines. 2022 May 21;10(5):1195. doi: 10.3390/biomedicines10051195.
To evaluate the embolic properties of different acrylic adhesive/iodized oil mixtures for lymphatic interventions. Polymerization of histoacryl (HA) (Bayer Healthcare) and glubran 2 (GL) (GEM) mixed with iodized oil (ratios 1:0-1:7) were investigated in lymphatic fluids with low and high triglyceride (low TG & high TG) contents. Static polymerization time and dynamic polymerization experiments with different volumes of glucose flush (1, 2 and 5 mL) were performed to simulate thoracic duct embolization. For both glues, static polymerization times were longer when the iodized oil content was increased and when performed in high TG lymphatic fluid. In the dynamic experiments, the prolongation of polymerization due to the oil content and TG levels was less pronounced for both glue types. Increased lymphatic flow rates decreased embolization times for low glue/oil ratios while preventing embolization for high glue/oil ratios. Higher glucose flush volumes increased occlusion times. Polymerization times of acrylic glue in a lymphatic fluid are prolonged by increasing the iodized oil concentration and triglyceride concentration as well as by using larger volumes of glucose flush. Increased lymphatic flow rates decrease embolization times for low glue/oil ratios and may prevent embolization for high glue/oil ratios.
评估不同丙烯酸粘合剂/碘化油混合物在淋巴介入治疗中的栓塞特性。研究了与碘化油混合（比例为1:0至1:7）的组织粘合剂（HA）（拜耳医疗保健公司）和医用胶水2（GL）（GEM公司）在低甘油三酯（低TG）和高甘油三酯（高TG）含量的淋巴液中的聚合情况。进行了静态聚合时间和不同葡萄糖冲洗体积（1、2和5 mL）的动态聚合实验，以模拟胸导管栓塞。对于两种胶水，当碘化油含量增加以及在高TG淋巴液中进行时，静态聚合时间会延长。在动态实验中，两种胶水因油含量和TG水平导致的聚合延长不太明显。淋巴流速增加会缩短低胶水/油比例时的栓塞时间，而高胶水/油比例时则会阻止栓塞。更高的葡萄糖冲洗体积会增加闭塞时间。通过增加碘化油浓度和甘油三酯浓度以及使用更大体积的葡萄糖冲洗，丙烯酸胶水在淋巴液中的聚合时间会延长。淋巴流速增加会缩短低胶水/油比例时的栓塞时间，高胶水/油比例时可能会阻止栓塞。
