Laohavisudhi Fonthip, Chunchai Titikorn, Ketchaikosol Natnicha, Thosaporn Wacharaporn, Chattipakorn Nipon, Chattipakorn Siriporn C
Department of Oral Biology and Oral Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Diagnostics (Basel). 2022 May 20;12(5):1275. doi: 10.3390/diagnostics12051275.
Several studies have reported an association between high expression of CD44 in different types of cancer. However, no study has reported a link among CD44 expression, other biomarkers, and the aggressiveness of salivary gland tumors.
A total of 38 specimens were obtained from non-tumorous salivary glands, benign and malignant tumors in salivary glands. Immunohistochemical analyses of CD44s, CD44v6, IL-1β, CXCL1, and CXCR2 were performed, and the area of positive cells was assessed.
We found that both CD44s and CXCR2 expression were increased in the benign and malignant groups. CD44v6 was also increased in both groups, but it had the highest level in the malignant group. IL-1β was the only biomarker that increased significantly in the malignant group in comparison to the other two groups.
CD44s, CD44v6, CXCR2, and IL-1β expressions were found to be higher in salivary gland tumors. However, IL-1β alone may play a crucial role in the aggressiveness of salivary gland tumors as this cytokine was expressed only in the malignant group with high expression associated with high-grade malignancy.
多项研究报告了不同类型癌症中CD44高表达之间的关联。然而，尚无研究报道CD44表达、其他生物标志物与涎腺肿瘤侵袭性之间的联系。
从非肿瘤性涎腺、涎腺良性和恶性肿瘤中总共获取了38个标本。对CD44s、CD44v6、IL-1β、CXCL1和CXCR2进行免疫组织化学分析，并评估阳性细胞面积。
我们发现，CD44s和CXCR2表达在良性和恶性组中均增加。CD44v6在两组中也增加，但在恶性组中水平最高。与其他两组相比，IL-1β是唯一在恶性组中显著增加的生物标志物。
发现CD44s、CD44v6、CXCR2和IL-1β在涎腺肿瘤中表达较高。然而，单独的IL-1β可能在涎腺肿瘤的侵袭性中起关键作用，因为这种细胞因子仅在恶性组中表达，且高表达与高级别恶性肿瘤相关。
