Song Yun Hye, Moon Jung Won, Kim Yoo Na, Woo Ji Young, Son Hye Joo, Lee Suk Hyun, Hwang Hee Sung
Department of Radiology, Hallym University Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07441, Korea.
Department of Nuclear Medicine, Dankook University Medical Center, Cheonan 31116, Korea.
Diagnostics (Basel). 2022 May 23;12(5):1292. doi: 10.3390/diagnostics12051292.
We investigated the role of [18F]FDG positron emission tomography/computed tomography (PET/CT) in evaluating ground-glass nodules (GGNs) by visual analysis and tissue fraction correction. A total of 40 pathologically confirmed ≥1 cm GGNs were evaluated visually and semiquantitatively. [18F]FDG uptake of GGN distinct from background lung activity was considered positive in visual analysis. In semiquantitative analysis, we performed tissue fraction correction for the maximum standardized uptake value (SUVmax) of GGN. Of the 40 GGNs, 25 (63%) were adenocarcinomas, 9 (23%) were minimally invasive adenocarcinomas (MIAs), and 6 (15%) were adenocarcinomas in situ (AIS). On visual analysis, adenocarcinoma showed the highest positivity rate among the three pathological groups (88%, 44%, and 17%, respectively). Both SUVmax and tissue-fraction−corrected SUVmax (SUVmaxTF) were in the order of adenocarcinoma > MIA > AIS (p = 0.033 and 0.018, respectively). SUVmaxTF was significantly higher than SUVmax before correction (2.4 [1.9−3.0] vs. 1.3 [0.8−1.8], p < 0.001). When using a cutoff value of 2.5, the positivity rate of GGNs was significantly higher in SUVmaxTF than in SUVmax (50% vs. 5%, p < 0.001). The diagnostic sensitivity of [18F]FDG PET/CT in predicting the malignancy of lung GGN was improved by tissue fraction correction and visual analysis.
我们通过视觉分析和组织分数校正研究了[18F]氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）在评估磨玻璃结节（GGN）中的作用。对40个经病理证实的直径≥1 cm的GGN进行了视觉和半定量评估。在视觉分析中，GGN的[18F]FDG摄取不同于背景肺组织活性被视为阳性。在半定量分析中，我们对GGN的最大标准化摄取值（SUVmax）进行了组织分数校正。40个GGN中，25个（63%）为腺癌，9个（23%）为微浸润腺癌（MIA），6个（15%）为原位腺癌（AIS）。在视觉分析中，腺癌在三个病理组中的阳性率最高（分别为88%、44%和17%）。SUVmax和组织分数校正后的SUVmax（SUVmaxTF）均为腺癌>MIA>AIS的顺序（p分别为0.033和0.018）。SUVmaxTF显著高于校正前的SUVmax（2.4[1.9 - 3.0] vs. 1.3[0.8 - 1.8]，p<0.001）。当使用截断值2.5时，GGN在SUVmaxTF中的阳性率显著高于SUVmax（50% vs. 5%，p<0.001）。[18F]FDG PET/CT在预测肺GGN恶性程度方面的诊断敏感性通过组织分数校正和视觉分析得到了提高。
