Dusic E J, Bowen Deborah J, Bennett Robin, Cain Kevin C, Theoryn Tesla, Velasquez Mariebeth, Swisher Elizabeth, Brant Jeannine M, Shirts Brian, Wang Catharine
Institute of Public Health Genetics, University of Washington, Seattle, WA 98105, USA.
Department of Bioethics, University of Washington, Seattle, WA 98105, USA.
Healthcare (Basel). 2022 May 10;10(5):880. doi: 10.3390/healthcare10050880.
Cancer is a significant burden, particularly to individuals of low socioeconomic status (SES). Genetic testing can provide information about an individual's risk of developing cancer and guide future screening and preventative services. However, there are significant financial barriers, particularly for individuals of low SES. This study used the Early Detection of Genetic Risk (EDGE) Study's patient baseline survey ( = 2329) to evaluate the relationship between socioeconomic status and interest in pursuing hereditary cancer genetic testing. Analysis was completed for two interest outcomes-overall interest in genetic testing and interest in genetic testing if the test were free or low cost. Many demographic and SES variables were predictors for interest in genetic testing, including education, income, and MacArthur Subjective Social Scale (SSS). After controlling for the healthcare system, age, and gender, having a higher education level and a higher household income were associated with greater general interest. Lower SSS was associated with greater interest in genetic testing if the test was free or low cost. If genetic testing is the future of preventative medicine, more work needs to be performed to make this option accessible to low-SES groups and to ensure that those services are used by the most underserved populations.
癌症是一项重大负担,对社会经济地位较低(SES)的个体而言尤甚。基因检测能够提供有关个体患癌风险的信息,并指导未来的筛查和预防服务。然而,存在重大的经济障碍,特别是对于社会经济地位较低的个体。本研究利用遗传风险早期检测(EDGE)研究的患者基线调查(n = 2329)来评估社会经济地位与进行遗传性癌症基因检测兴趣之间的关系。针对两个兴趣结果进行了分析——对基因检测的总体兴趣以及如果检测免费或低成本时对基因检测的兴趣。许多人口统计学和社会经济地位变量是基因检测兴趣的预测因素,包括教育程度、收入和麦克阿瑟主观社会量表(SSS)。在控制了医疗保健系统、年龄和性别之后,较高的教育水平和较高的家庭收入与更高的总体兴趣相关。较低的SSS与如果检测免费或低成本时对基因检测的更大兴趣相关。如果基因检测是预防医学的未来,就需要开展更多工作,以使社会经济地位较低的群体能够获得这一选择,并确保那些服务被最缺乏服务的人群所利用。