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羊水和胎盘膜作为干细胞的来源:进展与挑战。

Amniotic Fluid and Placental Membranes as Sources of Stem Cells: Progress and Challenges.

机构信息

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via del Pozzo 71, 41125 Modena, Italy.

Faculty of Bioscience and Agro-Food and Environmental Technology, Agriculture and Environment, University of Teramo, Via Renato Balzarini 1, 64100 Teramo, Italy.

出版信息

Int J Mol Sci. 2022 May 11;23(10):5362. doi: 10.3390/ijms23105362.

DOI:10.3390/ijms23105362
PMID:35628186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9141978/
Abstract

The intention of this special edition is to collect review and original research articles that illustrate and stimulate growing efforts to understand the implication of perinatal stem cells in pathological conditions such as cardiovascular and metabolic diseases and inflammatory, autoimmune, musculoskeletal, and degenerative diseases [...].

摘要

本期特刊的目的是收集综述和原始研究文章,说明和激发人们日益努力理解围产期干细胞在心血管和代谢疾病以及炎症、自身免疫、肌肉骨骼和退行性疾病等病理状况中的意义。

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Amniotic Fluid and Placental Membranes as Sources of Stem Cells: Progress and Challenges.羊水和胎盘膜作为干细胞的来源:进展与挑战。
Int J Mol Sci. 2022 May 11;23(10):5362. doi: 10.3390/ijms23105362.
2
Amniotic Fluid and Placental Membranes as Sources of Stem Cells: Progress and Challenges 2.0.羊膜和胎盘膜作为干细胞的来源:进展与挑战 2.0。
Int J Mol Sci. 2023 Nov 7;24(22):16020. doi: 10.3390/ijms242216020.
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Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells.羊膜和胎盘膜:具有多能性的细胞的意外来源。
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Amniotic fluid and placental stem cells.羊水和胎盘干细胞。
Methods Enzymol. 2006;419:426-38. doi: 10.1016/S0076-6879(06)19017-5.
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Human placental stem cells: biomedical potential and clinical relevance.人胎盘干细胞:生物医学潜力与临床相关性。
J Stem Cells. 2011;6(2):75-92.
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Current Status and Future Prospects of Perinatal Stem Cells.围产期干细胞的现状与展望。
Genes (Basel). 2020 Dec 23;12(1):6. doi: 10.3390/genes12010006.
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Value of placental microbial evaluation in diagnosing intra-amniotic infection.胎盘微生物评估在诊断羊膜腔内感染中的价值。
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A study of the relationship between placenta growth factor and gestational age, parturition, rupture of membranes, and intrauterine infection.胎盘生长因子与孕周、分娩、胎膜破裂及宫内感染之间关系的研究
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Amniotic fluid interleukin 6 and interleukin 8 are superior predictors of fetal lung injury compared with maternal or fetal plasma cytokines or placental histopathology in a nonhuman primate model.在非人灵长类动物模型中,与母血、脐血细胞因子或胎盘组织病理学比较,羊水白介素 6 和白介素 8 对胎儿肺损伤有更好的预测价值。
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Isolation of mesenchymal stem cells from amniotic fluid and placenta.从羊水和胎盘中分离间充质干细胞。
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Effects of stem cell therapy on preclinical stroke.干细胞疗法对临床前中风的影响。
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Placental mesenchymal stem cell-derived exosomes treat endometrial injury in a rat model of intrauterine adhesions.胎盘间充质干细胞来源的外泌体治疗大鼠宫腔粘连模型中的子宫内膜损伤。
Mol Genet Genomics. 2025 Mar 25;300(1):36. doi: 10.1007/s00438-025-02241-x.
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Cell-based therapies have disease-modifying effects on osteoarthritis in animal models: A systematic review by the ESSKA Orthobiologic Initiative. Part 3: Umbilical cord, placenta, and other sources for cell-based injectable therapies.基于细胞的疗法对动物模型中的骨关节炎具有疾病修饰作用:ESSKA 骨科生物治疗倡议的系统评价。第3部分:脐带、胎盘及其他基于细胞的注射疗法来源。
Knee Surg Sports Traumatol Arthrosc. 2025 May;33(5):1695-1708. doi: 10.1002/ksa.12472. Epub 2024 Sep 20.
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Synergistic potential of stem cells and microfluidics in regenerative medicine.干细胞与微流控技术在再生医学中的协同潜力。
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The future of diabetic wound healing: unveiling the potential of mesenchymal stem cell and exosomes therapy.糖尿病伤口愈合的未来:揭示间充质干细胞和外泌体疗法的潜力。
Am J Stem Cells. 2024 Apr 25;13(2):87-100. doi: 10.62347/OVBK9820. eCollection 2024.
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Stem-Cell-Driven Chondrogenesis: Perspectives on Amnion-Derived Cells.干细胞驱动的软骨生成:羊膜源性细胞的观点。
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Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial.评价一种用羊水配方制成的凝胶对糖尿病足溃疡愈合效果的影响:一项三盲临床试验。
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Placental stem cells-derived exosomes stimulate cutaneous wound regeneration engrailed-1 inhibition.胎盘干细胞衍生的外泌体刺激皮肤伤口再生并抑制engrailed-1。
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本文引用的文献

1
Comprehensive Profiling of Secretome Formulations from Fetal- and Perinatal Human Amniotic Fluid Stem Cells.全面分析胎牛和围产人羊膜干细胞分泌组制剂。
Int J Mol Sci. 2021 Apr 2;22(7):3713. doi: 10.3390/ijms22073713.
2
Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells.人羊膜来源干细胞的特征和治疗潜力。
Int J Mol Sci. 2021 Jan 19;22(2):970. doi: 10.3390/ijms22020970.
3
Conditioned Medium from Human Amnion-Derived Mesenchymal Stromal/Stem Cells Attenuating the Effects of Cold Ischemia-Reperfusion Injury in an In Vitro Model Using Human Alveolar Epithelial Cells.人羊膜来源间充质基质/干细胞条件培养基减轻人肺泡上皮细胞体外模型中冷缺血再灌注损伤的作用。
Int J Mol Sci. 2021 Jan 6;22(2):510. doi: 10.3390/ijms22020510.
4
Amniotic Fluid Stem Cell-Derived Extracellular Vesicles Counteract Steroid-Induced Osteoporosis In Vitro.羊膜干细胞衍生的细胞外囊泡可对抗体外激素诱导的骨质疏松症。
Int J Mol Sci. 2020 Dec 22;22(1):38. doi: 10.3390/ijms22010038.
5
Progress and Challenges of Amniotic Fluid Derived Stem Cells in Therapy of Ischemic Heart Disease.羊水来源干细胞在缺血性心脏病治疗中的进展与挑战。
Int J Mol Sci. 2020 Dec 24;22(1):102. doi: 10.3390/ijms22010102.
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Prophylactic Therapy with Human Amniotic Fluid Stem Cells Improves Long-Term Cognitive Impairment in Rat Neonatal Sepsis Survivors.人羊膜干细胞预防性治疗可改善新生儿败血症幸存者的长期认知障碍。
Int J Mol Sci. 2020 Dec 16;21(24):9590. doi: 10.3390/ijms21249590.
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The Effect of Angiotensin II, Retinoic Acid, EGCG, and Vitamin C on the Cardiomyogenic Differentiation Induction of Human Amniotic Fluid-Derived Mesenchymal Stem Cells.血管紧张素 II、维甲酸、EGCG 和维生素 C 对人羊膜间充质干细胞成心肌诱导分化的影响。
Int J Mol Sci. 2020 Nov 19;21(22):8752. doi: 10.3390/ijms21228752.
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Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications.人羊膜上皮干细胞:一种有前途的临床应用种子细胞。
Int J Mol Sci. 2020 Oct 19;21(20):7730. doi: 10.3390/ijms21207730.
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In Vitro Innovation of Tendon Tissue Engineering Strategies.体外创新的肌腱组织工程策略。
Int J Mol Sci. 2020 Sep 14;21(18):6726. doi: 10.3390/ijms21186726.
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Dose-Response Tendon-Specific Markers Induction by Growth Differentiation Factor-5 in Human Bone Marrow and Umbilical Cord Mesenchymal Stem Cells.生长分化因子 5 诱导人骨髓和脐带来源间充质干细胞产生肌腱特异性标志物。
Int J Mol Sci. 2020 Aug 17;21(16):5905. doi: 10.3390/ijms21165905.