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干细胞与微流控技术在再生医学中的协同潜力。

Synergistic potential of stem cells and microfluidics in regenerative medicine.

作者信息

Rajalekshmi Resmi, Agrawal Devendra K

机构信息

Department of Translational Research, Western University of Health Sciences, 309 E. Second Street, Pomona, CA, 91766, USA.

出版信息

Mol Cell Biochem. 2025 Mar;480(3):1481-1493. doi: 10.1007/s11010-024-05108-8. Epub 2024 Sep 16.

Abstract

Regenerative medicine has immense potential to revolutionize healthcare by using regenerative capabilities of stem cells. Microfluidics, a cutting-edge technology, offers precise control over cellular microenvironments. The integration of these two fields provides a deep understanding of stem cell behavior and enables the development of advanced therapeutic strategies. This critical review explores the use of microfluidic systems to culture and differentiate stem cells with precision. We examined the use of microfluidic platforms for controlled nutrient supply, mechanical stimuli, and real-time monitoring, providing an unprecedented level of detail in studying cellular responses. The convergence of stem cells and microfluidics holds immense promise for tissue repair, regeneration, and personalized medicine. It offers a unique opportunity to revolutionize the approach to regenerative medicine, facilitating the development of advanced therapeutic strategies and enhancing healthcare outcomes.

摘要

再生医学利用干细胞的再生能力,具有彻底改变医疗保健的巨大潜力。微流控技术作为一项前沿技术,能够对细胞微环境进行精确控制。这两个领域的融合有助于深入了解干细胞行为,并推动先进治疗策略的发展。这篇批判性综述探讨了如何利用微流控系统精确培养和分化干细胞。我们研究了微流控平台在控制营养供应、施加机械刺激和实时监测方面的应用,为研究细胞反应提供了前所未有的详细信息。干细胞与微流控技术的结合为组织修复、再生和个性化医疗带来了巨大希望。它为彻底改变再生医学的方法提供了独特的机会,有助于先进治疗策略的开发,并改善医疗保健成果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52fc/11842489/b75f624a3e26/11010_2024_5108_Fig1_HTML.jpg

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