Division of Endocrinology, Department of Clinical and Molecular Sciences (DISCLIMO), Polytechnic University of Marche, 60126 Ancona, Italy.
Int J Mol Sci. 2022 May 14;23(10):5497. doi: 10.3390/ijms23105497.
Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.
代谢综合征（MetS）是成年男性中一种高发疾病，在欧洲高达 41%的男性受其影响。它的特征是肥胖、高血压和致动脉粥样硬化性血脂异常的联合，这导致了由于心血管疾病（CVD）引起的过早发病和死亡。男性不育症是另一种常见疾病，占全球夫妇不育病例的约 50%。有趣的是，男性不育症和 MetS 有几个共同的风险因素（例如，吸烟、衰老、缺乏身体活动和过度饮酒），这导致了活性氧（ROS）的产生和氧化应激（OS）的增加，进而导致内皮功能障碍和精液质量改变。因此，本综述旨在讨论将男性不育症和 MetS 联系起来的病理生理机制，并研究 MetS 对生殖的最新可用证据。
