Department of Dermatology, Far Eastern Memorial Hospital, New Taipei 220, Taiwan.
Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan.
Int J Mol Sci. 2022 May 15;23(10):5518. doi: 10.3390/ijms23105518.
Psoriasis (PSO) and atopic dermatitis (AD) were once considered to be mutually exclusive diseases, but gradually regarded as a spectrum of disease. Shared genetic loci of both diseases were noted in some populations, including Chinese. Shared immunopathogenesis involving Th17, Th1, Th22 cells, or even IL-13 was found in certain stages or phenotypes. This review discusses the overlapping genetic susceptibility, shared cytokines, immune-mediated comorbidities, and clinical presentations. Overlapping conditions could be classified into mainly PSO lesions with AD features or vice versa, concomitant PSO and AD, or disease transformation as a result of biologics treatment.
银屑病（PSO）和特应性皮炎（AD）曾被认为是相互排斥的疾病，但逐渐被认为是一种疾病谱。在一些人群中，包括中国人，两种疾病存在共享的遗传位点。在某些阶段或表型中发现了涉及 Th17、Th1、Th22 细胞甚至 IL-13 的共同免疫发病机制。本综述讨论了重叠的遗传易感性、共同的细胞因子、免疫介导的合并症和临床表现。重叠的情况可以分为主要为 PSO 病变伴 AD 特征或以相反，同时存在 PSO 和 AD，或由于生物制剂治疗导致疾病转化。
