Xie Yan, Peng Xinrui, Yin Jian-Kai, Lu Xinyi, Ye Yang, Chen Yu, Wu Juan, Sun Yan, Gu Ying
Affiliated Women's Hospital of Jiangnan University, Jiangnan University, Jiangsu, 214002, China.
Shunwde People's Hospital, Guangdong, 528300, China.
Sci Rep. 2025 Mar 28;15(1):10796. doi: 10.1038/s41598-025-91814-2.
This study aimed to elucidate the association between the body roundness index (BRI), an indicator of abdominal obesity, and the odds of developing psoriasis. We conducted a comprehensive, multi-ethnic cross-sectional analysis utilizing data from the National Health and Nutrition Examination Survey (NHANES). Height and weight measurements were obtained from the database, recorded by trained personnel using standardized equipment. In addition, demographic and clinical information was collected via questionnaires. The association between BRI and psoriasis odds was assessed using multivariable weighted logistic regression models, and the relationship was further visualized through restricted cubic spline (RCS) curves. Subgroup analyses were conducted to explore this association across different populations, and sensitivity analyses were performed using unweighted methods to validate the findings. The study encompassed 21,242 participants, of whom 562 were diagnosed with psoriasis. Comparative analyses of clinical and demographic characteristics between psoriasis and non-psoriasis groups revealed statistically significant differences. The weighted logistic regression analysis demonstrated a positive association between BRI and the occurrence of psoriasis, with BRI considered both as a continuous and a categorical variable. Specifically, each unit increase in BRI was associated with a 9% increase in the odds of psoriasis (95% confidence interval: 4% to 13%). The RCS curves indicated a progressive increase in psoriasis odds with rising BRI levels. Subgroup analyses consistently showed a significant positive correlation between BRI and psoriasis odds across diverse populations. The sensitivity analysis corroborated the main findings, underscoring the robustness of our conclusions. Our findings establish a significant and reliable positive association between BRI, a marker of abdominal obesity, and the odds of psoriasis across various populations.
本研究旨在阐明腹部肥胖指标——身体圆润度指数（BRI）与患银屑病几率之间的关联。我们利用来自美国国家健康与营养检查调查（NHANES）的数据进行了一项全面的、多民族横断面分析。身高和体重测量数据来自数据库，由经过培训的人员使用标准化设备记录。此外，通过问卷调查收集了人口统计学和临床信息。使用多变量加权逻辑回归模型评估BRI与银屑病几率之间的关联，并通过受限立方样条（RCS）曲线进一步直观展示这种关系。进行亚组分析以探究不同人群中的这种关联，并使用非加权方法进行敏感性分析以验证研究结果。该研究纳入了21242名参与者，其中562人被诊断患有银屑病。银屑病组与非银屑病组之间临床和人口统计学特征的比较分析显示出统计学上的显著差异。加权逻辑回归分析表明，BRI与银屑病的发生呈正相关，BRI被视为连续变量和分类变量。具体而言，BRI每增加一个单位，患银屑病的几率就增加9%（95%置信区间：4%至13%）。RCS曲线表明，随着BRI水平升高，患银屑病的几率逐渐增加。亚组分析一致显示，在不同人群中BRI与银屑病几率之间存在显著正相关。敏感性分析证实了主要研究结果，强调了我们结论的稳健性。我们的研究结果在腹部肥胖标志物BRI与不同人群患银屑病的几率之间建立了显著且可靠的正相关。
