Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy.
Int J Mol Sci. 2022 May 22;23(10):5814. doi: 10.3390/ijms23105814.
Insulin resistance (IR) is a key component in the etiopathogenesis of hypertension (HS) in patients with diabetes mellitus (DM). Several pathways have been found to be involved in this mechanism in recent literature. For the above-mentioned reasons, treatment of HS should be specifically addressed in patients affected by DM. Two relevant recently published guidelines have stressed this concept, giving specific advice in the treatment of HS in children belonging to this group: the European Society of HS guidelines for the management of high blood pressure in children and adolescents and the American Academy of Pediatrics Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents. Our aim is to summarize the main pathophysiological mechanisms through which IR causes HS and to highlight the specific principles of treatment of HS for children with DM.
胰岛素抵抗（IR）是糖尿病（DM）患者高血压（HS）发病机制中的一个关键组成部分。最近的文献中发现了几种与该机制相关的途径。基于上述原因，DM 患者的 HS 治疗应特别关注。最近发表的两份相关指南强调了这一概念，为该人群中的儿童 HS 治疗提供了具体建议：欧洲 HS 学会儿童和青少年高血压管理指南和美国儿科学会儿童和青少年高血压筛查和管理临床实践指南。我们的目的是总结 IR 导致 HS 的主要病理生理机制，并强调 DM 儿童 HS 治疗的具体原则。
