van Rotterdam A, Barendsen G W, Gaiser J F
Radiother Oncol. 1987 Feb;8(2):171-6. doi: 10.1016/s0167-8140(87)80171-8.
Two experimental tumour models, a rat rhabdomyosarcoma (R-1) and a rat urether carcinoma (RUC-2) have been employed to evaluate the X-ray sensitivity of tumours recurrent after primary treatments with various doses of X-rays and to correlate changes in volume responses with the cellular radiosensitivity. The responsiveness of R-1 tumours, assessed from the volume reduction as a function of the time after treatment, was less for recurrent tumours, but their growth delay was slightly increased, while the X-ray sensitivity of the tumour cells, assessed by cell survival, was equal to that of the controls. For RUC-2 tumours, however, the reduction in volume after irradiation of the recurrent tumour was larger than after primary treatment, the growth delay was increased, but cell survival curves were not significantly different from those of the controls. It is concluded that differences in volume responses between untreated tumours and recurrent tumours are largely determined by a tumour bed effect (TBE) and that changes in cellular radiosensitivity in these tumours do not play a significant part.
两种实验性肿瘤模型，即大鼠横纹肌肉瘤（R-1）和大鼠输尿管癌（RUC-2），已被用于评估经不同剂量X射线初次治疗后复发肿瘤的X射线敏感性，并将体积反应的变化与细胞放射敏感性相关联。从治疗后作为时间函数的体积减小来评估，R-1肿瘤复发后的反应性较小，但其生长延迟略有增加，而通过细胞存活评估的肿瘤细胞的X射线敏感性与对照相等。然而，对于RUC-2肿瘤，复发肿瘤照射后的体积减小比初次治疗后更大，生长延迟增加，但细胞存活曲线与对照无显著差异。得出的结论是，未治疗肿瘤和复发肿瘤之间体积反应的差异在很大程度上由肿瘤床效应（TBE）决定，并且这些肿瘤中细胞放射敏感性的变化不起重要作用。
