Di Marco Maurizio, Urbano Francesca, Filippello Agnese, Di Mauro Stefania, Scamporrino Alessandra, Miano Nicoletta, Coppolino Giuseppe, L'Episcopo Giuseppe, Leggio Stefano, Scicali Roberto, Piro Salvatore, Purrello Francesco, Di Pino Antonino
Department of Clinical and Experimental Medicine, University of Catania, 95131 Catania, Italy.
J Clin Med. 2022 May 19;11(10):2870. doi: 10.3390/jcm11102870.
Alterations of glucose homeostasis are associated with subclinical vascular damage; however, the role of platelet reactivity in this process has not been fully investigated. In this cross-sectional study, we evaluated the correlation between markers of platelet reactivity and inflammation and markers of vascular disease in subjects with prediabetes. Markers of platelet reactivity such as 11-dehydro-thromboxane B2 urinary levels (11-dh-TXB2) and mean platelet volume (MPV) and inflammatory indexes such as platelet-to-lymphocyte ratio (PLR) were evaluated in subjects with prediabetes ( = 48), new-onset type 2 diabetes (NODM, = 60) and controls ( = 62). Furthermore, we assessed the cardiovascular risk profile of the study population with arterial stiffness and quality intima-media thickness (qIMT). Subjects with prediabetes and NODM exhibited higher 11-dh-TXB2 urinary levels and MPV and a proinflammatory profile with an increased PLR, high-sensitivity C-reactive protein, ferritin and fibrinogen. Furthermore, after multiple regression analyses, we found that urinary 11-dh-TXB2 was one of the major determinants of IMT and arterial stiffness parameters. In conclusion, subjects with prediabetes exhibit increased platelet reactivity as well as a proinflammatory profile. Furthermore, this condition is associated with early markers of cardiovascular disease.
葡萄糖稳态的改变与亚临床血管损伤有关；然而，血小板反应性在此过程中的作用尚未得到充分研究。在这项横断面研究中，我们评估了糖尿病前期患者血小板反应性标志物与炎症以及血管疾病标志物之间的相关性。在糖尿病前期患者（n = 48）、新发2型糖尿病患者（NODM，n = 60）和对照组（n = 62）中评估了血小板反应性标志物，如11 - 脱氢血栓素B2尿水平（11 - dh - TXB2）和平均血小板体积（MPV），以及炎症指标，如血小板与淋巴细胞比值（PLR）。此外，我们用动脉僵硬度和内膜中层厚度质量（qIMT）评估了研究人群的心血管风险状况。糖尿病前期患者和NODM患者表现出较高的11 - dh - TXB2尿水平和MPV，以及炎症前状态，伴有PLR、高敏C反应蛋白、铁蛋白和纤维蛋白原升高。此外，经过多元回归分析，我们发现尿11 - dh - TXB2是内膜中层厚度和动脉僵硬度参数的主要决定因素之一。总之，糖尿病前期患者表现出血小板反应性增加以及炎症前状态。此外，这种情况与心血管疾病的早期标志物有关。
