Faculty of Health Sciences, University of Talca, Talca 3460000, Chile.
Facultad de Ciencias de la Salud, Escuela de Tecnología Médica, Universidad Bernardo OHiggins, General Gana 1702, Santiago 8370854, Chile.
Cells. 2022 Mar 17;11(6):1014. doi: 10.3390/cells11061014.
Platelets play important roles in thrombosis-dependent obstructive cardiovascular diseases. In addition, it has now become evident that platelets also participate in the earliest stages of atherosclerosis, including the genesis of the atherosclerotic lesion. Moreover, while the link between platelet activity and hemostasis has been well established, the role of platelets as modulators of inflammation has only recently been recognized. Thus, through their secretory activities, platelets can chemically attract a diverse repertoire of cells to inflammatory foci. Although monocytes and lymphocytes act as key cells in the progression of an inflammatory event and play a central role in plaque formation and progression, there is also evidence that platelets can traverse the endothelium, and therefore be a direct mediator in the progression of atherosclerotic plaque. This review provides an overview of platelet interactions and regulation in atherosclerosis.
血小板在血栓依赖性阻塞性心血管疾病中发挥着重要作用。此外，现在已经很明显，血小板也参与动脉粥样硬化的早期阶段，包括动脉粥样硬化病变的发生。此外，虽然血小板活性与止血之间的联系已经得到很好的确立，但血小板作为炎症调节剂的作用直到最近才被认识到。因此，通过它们的分泌活动，血小板可以化学吸引各种细胞到炎症焦点。虽然单核细胞和淋巴细胞作为炎症事件进展的关键细胞，在斑块形成和进展中起着核心作用，但也有证据表明血小板可以穿过内皮细胞，因此在动脉粥样硬化斑块的进展中是直接的介导者。本综述提供了血小板在动脉粥样硬化中的相互作用和调节的概述。
