Licordari Roberto, Sticchi Alessandro, Mancuso Filippo, Caracciolo Alessandro, Muscoli Saverio, Iacovelli Fortunato, Ruggiero Rossella, Scoccia Alessandra, Cammalleri Valeria, Pavani Marco, Loffi Marco, Scordino Domenico, Ferro Jayme, Rognoni Andrea, Buono Andrea, Nava Stefano, Albani Stefano, Colaiori Iginio, Zilio Filippo, Borghesi Marco, Regazzoni Valentina, Benenati Stefano, Pescetelli Fabio, De Marzo Vincenzo, Mannarini Antonia, Spione Francesco, Baldassarre Doronzo, De Benedictis Michele, Bonmassari Roberto, Danzi Gian Battista, Galli Mario, Ielasi Alfonso, Musumeci Giuseppe, Tomai Fabrizio, Pasceri Vincenzo, Porto Italo, Patti Giuseppe, Campo Gianluca, Colombo Antonio, Micari Antonio, Giannini Francesco, Costa Francesco
Department of Clinical and Experimental Medicine, Policlinic "G Martino", University of Messina, 98124 Messina, Italy.
GVM Care & Research, Maria Cecilia Hospital, 48033 Cotignola, Italy.
J Clin Med. 2022 May 22;11(10):2926. doi: 10.3390/jcm11102926.
The COVID-19 pandemic increased the complexity of the clinical management and pharmacological treatment of patients presenting with an Acute Coronary Syndrome (ACS).
to explore the incidence and prognostic impact of in-hospital bleeding in patients presenting with ACS before and during the COVID-19 pandemic.
We evaluated in-hospital Thrombolysis In Myocardial Infarction (TIMI) major and minor bleeding among 2851 patients with ACS from 17 Italian centers during the first wave of the COVID-19 pandemic (i.e., March-April 2020) and in the same period in the previous two years.
The incidence of in-hospital TIMI major and minor bleeding was similar before and during the COVID-19 pandemic. TIMI major or minor bleeding was associated with a significant threefold increase in all-cause mortality, with a similar prognostic impact before and during the COVID-19 pandemic.
the incidence and clinical impact of in-hospital bleeding in ACS patients was similar before and during the COVID-19 pandemic. We confirmed a significant and sizable negative prognostic impact of in-hospital bleeding in ACS patients.
新型冠状病毒肺炎（COVID-19）大流行增加了急性冠状动脉综合征（ACS）患者临床管理和药物治疗的复杂性。
探讨COVID-19大流行之前和期间ACS患者院内出血的发生率及其对预后的影响。
我们评估了在COVID-19大流行第一波期间（即2020年3月至4月）以及前两年同期，来自17个意大利中心的2851例ACS患者的院内心肌梗死溶栓（TIMI）严重和轻微出血情况。
COVID-19大流行之前和期间，院内TIMI严重和轻微出血的发生率相似。TIMI严重或轻微出血与全因死亡率显著增加三倍相关，在COVID-19大流行之前和期间对预后的影响相似。
COVID-19大流行之前和期间，ACS患者院内出血的发生率和临床影响相似。我们证实了院内出血对ACS患者有显著且相当大的负面预后影响。
