Wickrama Kandauda A S, Ralston Penny A, Ilich Jasminka Z
Department of Human Development and Family Science, University of Georgia, Athens, GA 30602, USA.
Center on Better Health and Life for Underserved Populations, Florida State University, Tallahassee, FL 32306, USA.
J Pers Med. 2022 May 4;12(5):745. doi: 10.3390/jpm12050745.
Both lower life satisfaction (LLS) and chronic inflammation are underlying conditions for numerous diseases. We investigated their associations in African American adults, within the context of three hypotheses: (a) perceived LLS will be positively associated with inflammation measured by serum C-reactive protein (CRP); (b) this association will be mediated by body adiposity; and (c) these associations will be moderated by sex. Participants (n = 83; >45 years; 59% women) were a subsample of a larger church-based intervention to reduce cardiovascular risks and were assessed at baseline and after 6 months. Body adiposity (BMI/hip/waist circumferences) was measured by standardized methods and CRP with ELISA. LLS was self-reported. The analyses were conducted in the structural equation modeling (SEM) framework. The direct relationship between LLS and CRP was significant for all participants but was mediated by BMI/hip/waist circumferences. Multi-group SEM analysis provided evidence for sex moderation by showing that the mediating pathway from LLS to CRP through BMI, and to a lesser extent through hip/waist circumferences, was significant only in women. In conclusion, perceived LLS was positively associated with the level of inflammation mediated by BMI/hip/waist circumference, with the association between LLS and CRP being stronger in women. These findings contribute to the current literature untangling mediation/moderation processes in which perceived LLS may contribute to adiposity-related inflammation. They also add to precision medicine development, suggesting that stress and inflammation-reducing interventions should focus on African Americans, particularly women.
较低的生活满意度（LLS）和慢性炎症都是多种疾病的潜在病因。我们在三个假设的背景下，对非裔美国成年人中它们之间的关联进行了调查：（a）感知到的LLS将与通过血清C反应蛋白（CRP）测量的炎症呈正相关；（b）这种关联将由身体肥胖介导；（c）这些关联将受到性别的调节。参与者（n = 83；年龄>45岁；59%为女性）是一项基于教堂的更大规模心血管风险降低干预措施的子样本，并在基线和6个月后进行了评估。通过标准化方法测量身体肥胖（BMI/臀围/腰围），并用酶联免疫吸附测定法测量CRP。LLS通过自我报告获得。分析在结构方程模型（SEM）框架内进行。LLS与CRP之间的直接关系对所有参与者都具有显著性，但由BMI/臀围/腰围介导。多组SEM分析通过表明从LLS到CRP通过BMI以及在较小程度上通过臀围/腰围的中介途径仅在女性中具有显著性，为性别调节提供了证据。总之，感知到的LLS与由BMI/臀围/腰围介导的炎症水平呈正相关，LLS与CRP之间的关联在女性中更强。这些发现为当前解开感知到的LLS可能导致与肥胖相关炎症的中介/调节过程的文献做出了贡献。它们也为精准医学的发展增添了内容，表明减轻压力和炎症的干预措施应侧重于非裔美国人，尤其是女性。
