Lin Chia-Yen, Chang Ting-Ya, Chang Ming-Hong
Department of Neurology, Neurological Institute, Taichung Veterans General Hospital, No. 1650, Taiwan Boulevard, Sect. 4, Taichung 40705, Taiwan.
Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, No. 145, XingDa Road, South Dist., Taichung 40227, Taiwan.
J Pers Med. 2022 May 6;12(5):754. doi: 10.3390/jpm12050754.
(1) Background: The correlation between dysosmia with quality of life (QoL) in patients with PD was rarely reported. The study aimed to examine the effect of dysosmia on motor function and QoL in PD. (2) Methods: This cross-sectional study, performed between October 2016 and February 2021, recorded the traditional Chinese version of the University of Pennsylvania Smell Identification Test (UPSIT), the Montreal Cognitive Assessment (MoCA), the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS UPDRS), and the 39-item Parkinson’s Disease Questionnaire (PDQ-39) in patients with PD. UPSIT = 19 was applied to separate the total anosmia and non-anosmia groups. (3) Results: 243 patients with PD were recruited. The total anosmia group had higher MDS UPDRS total, part II, and part III scores than the non-anosmia group. They also had worse scores on the dimensions of activities of daily living (ADL) and cognition of the PDQ-39 than the non-anosmia group. The UPSIT score correlated MDS UPDRS part III score (p < 0.0001), PDQ-39 ADL quartile (p = 0.0202), and Dopamine transporter scan (p = 0.0082) in the linear regression. (4) Conclusions: Dysosmia in PD predicted a phenotype with defective motor function, ADL, and cognition QoL. The findings supported the olfactory transmission of α-synuclein to the cortices, substantia nigra.
(1) 背景：帕金森病（PD）患者嗅觉障碍与生活质量（QoL）之间的相关性鲜有报道。本研究旨在探讨嗅觉障碍对PD患者运动功能和生活质量的影响。(2) 方法：这项横断面研究于2016年10月至2021年2月进行，记录了PD患者的中文版宾夕法尼亚大学嗅觉识别测试（UPSIT）、蒙特利尔认知评估（MoCA）、运动障碍协会赞助修订的统一帕金森病评定量表（MDS UPDRS）以及39项帕金森病问卷（PDQ - 39）。以UPSIT = 19区分完全嗅觉丧失组和非嗅觉丧失组。(3) 结果：招募了243例PD患者。完全嗅觉丧失组的MDS UPDRS总分、第二部分和第三部分得分高于非嗅觉丧失组。他们在PDQ - 39的日常生活活动（ADL）和认知维度上的得分也比非嗅觉丧失组差。在线性回归中，UPSIT得分与MDS UPDRS第三部分得分（p < 0.0001）、PDQ - 39 ADL四分位数（p = 0.0202）以及多巴胺转运体扫描（p = 0.0082）相关。(4) 结论：PD患者的嗅觉障碍预示着运动功能、ADL和认知生活质量存在缺陷的表型。这些发现支持α - 突触核蛋白向皮质、黑质的嗅觉传递。
