Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Department of Neurology, Suita Municipal Hospital, Osaka, Japan.
J Neurol Sci. 2024 Nov 15;466:123253. doi: 10.1016/j.jns.2024.123253. Epub 2024 Sep 29.
Parkinson's disease (PD) is a neurodegenerative disorder that causes a variety of motor and non-motor symptoms (NMS), which affect the patient's quality of life (QOL). This study aimed to compare QOL and background in patients with PD based on the disease duration and investigate the factors affecting QOL. Patients with PD were evaluated based on age, sex, disease duration (≤5 years and > 5 years groups), Mini Mental State Examination (MMSE), Japanese version of Montreal Cognitive Assessment (MoCA-J), Levodopa equivalent daily dose (LEDD), Hoehn and Yahr (HY) severity, movement disorder society-sponsored revision of the unified Parkinson's disease rating scale (MDS-UPDRS) parts I-IV, and QOL using the Parkinson's disease questionnaire (PDQ-8). Overall, 102 patients with PD (58 males; mean age = 70.0 years; mean disease duration = 7.3 years) were included in this study. QOL was significantly correlated (r > 0.30, p < 0.05) with disease duration and MDS-UPDRS parts I-IV total scores. When the PDQ-8 total score was compared with MDS-UPDRS parts I-IV total scores based on disease duration classification, it was positively correlated with the scores for parts I and II in the >5 years group. Moreover, MDS-UPDRS parts I and II total scores appeared to be the factors most significantly affecting QOL. The factors affecting QOL in patients with PD were subjective NMS and motor symptoms. Since, physician-rated motor symptoms were not associated with QOL in patients with >5 years PD, subjective symptoms should be evaluated and treated to maintain QOL.
帕金森病（PD）是一种神经退行性疾病，可导致多种运动和非运动症状（NMS），从而影响患者的生活质量（QOL）。本研究旨在根据疾病持续时间比较 PD 患者的 QOL 和背景，并探讨影响 QOL 的因素。根据年龄、性别、疾病持续时间（≤5 年和>5 年组）、简易精神状态检查（MMSE）、蒙特利尔认知评估的日本版（MoCA-J）、左旋多巴等效日剂量（LEDD）、Hoehn 和 Yahr（HY）严重程度、运动障碍协会修订的统一帕金森病评定量表（MDS-UPDRS）第 I-IV 部分和使用帕金森病问卷（PDQ-8）对 PD 患者进行评估。本研究共纳入 102 例 PD 患者（58 例男性；平均年龄 70.0 岁；平均疾病持续时间 7.3 年）。QOL 与疾病持续时间和 MDS-UPDRS 第 I-IV 部分总分呈显著相关（r>0.30，p<0.05）。当根据疾病持续时间分类比较 PDQ-8 总分与 MDS-UPDRS 第 I-IV 部分总分时，它与>5 年组第 I 和第 II 部分的得分呈正相关。此外，MDS-UPDRS 第 I 和 II 部分总分似乎是影响 QOL 的最重要因素。影响 PD 患者 QOL 的因素是主观 NMS 和运动症状。由于>5 年 PD 患者的医生评定的运动症状与 QOL 无关，因此应评估和治疗主观症状以维持 QOL。
