Department of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
Department of Oral Health, University of Medicine and Pharmacy "Iuliu Hatieganu", 400012 Cluj-Napoca, Romania.
Medicina (Kaunas). 2022 Apr 23;58(5):580. doi: 10.3390/medicina58050580.
The aim of this systematic review was to assess the electronic literature about the benefits of using hyaluronic acid (HA) in the surgical periodontal treatment of infrabony defects. This review was conducted under the PRISMA guidelines. The electronic search was conducted on PubMed, Scopus, Web of Science, and Cochrane databases until February 2022. The inclusion criteria consisted of human clinical trials that reported the use of HA in open-flap debridement (OFD) for infrabony defects. The assessment of risk of bias was performed using the Cochrane risk of bias tool. Statistical analysis was performed using Review Manager. Overall, three RCTs were found eligible for the statistical analysis. Probing depth (PD) reduction and clinical attachment level (CAL) gain in the HA test group presented WMs of -1.11 mm (95% CI -2.38 to 0.16 mm; = 0.09) and -1.38 mm (95% CI -2.26 to -0.49 mm; = 0.002), respectively. However, the heterogeneity of the RCTs was high, and the risk of bias, in general, was low. The use of hyaluronic acid seems to have beneficial effects in periodontal surgery using OFD, in terms of PD and CAL. To draw a clear conclusion, more adapted and well-designed clinical trials are needed to assess the advantage of this product in comparison with other products.
本系统评价的目的是评估电子文献中关于在牙周手术治疗骨下袋缺损中使用透明质酸（HA）的益处。本评价遵循 PRISMA 指南进行。电子检索在 PubMed、Scopus、Web of Science 和 Cochrane 数据库中进行，截至 2022 年 2 月。纳入标准包括报告在开放翻瓣术（OFD）中使用 HA 治疗骨下袋缺损的人类临床试验。使用 Cochrane 偏倚风险工具评估偏倚风险。使用 Review Manager 进行统计分析。总体而言，有三项 RCT 符合纳入标准进行统计分析。HA 试验组的探诊深度（PD）减少和临床附着水平（CAL）增加的 WMD 分别为-1.11mm（95%CI-2.38 至 0.16mm； = 0.09）和-1.38mm（95%CI-2.26 至-0.49mm； = 0.002）。然而，RCT 的异质性较高，总体偏倚风险较低。在使用 OFD 的牙周手术中，使用透明质酸似乎具有有益的效果，在 PD 和 CAL 方面。为了得出明确的结论，需要进行更多适应性强和设计良好的临床试验，以评估该产品与其他产品相比的优势。
