School of Chemistry and Materials Science, Jiangsu Normal University, Xuzhou 221116, China.
Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Molecules. 2022 May 11;27(10):3088. doi: 10.3390/molecules27103088.
As one of the abundant and inexpensive metals on the earth, copper has demonstrated broad applications in synthetic chemistry and catalysis. Among these copper-catalyzed advances, copper carbenes are versatile and reactive intermediates that can mediate a variety of transformations, which have attracted much attention in the past decades. The present review summarizes two different reaction models that take place between a copper carbene intermediate and alkyne species, including the cross-coupling reaction of copper carbene intermediate with terminal alkyne, and the addition of copper carbene intermediate onto the C-C triple bond. This article will cover the profile from 2010 to 2021 by placing emphasis on the detailed catalytic models and highlighting the synthetic applications offered by these practical and mild methods.
铜是地球上储量丰富且价格低廉的金属之一，在合成化学和催化领域有着广泛的应用。在这些铜催化的进展中，铜卡宾是多功能且反应性的中间体，可以介导多种转化，这在过去几十年中引起了广泛关注。本综述总结了铜卡宾中间体与炔烃之间发生的两种不同反应模型，包括铜卡宾中间体与末端炔烃的交叉偶联反应，以及铜卡宾中间体加成到 C-C 三键上。本文将重点介绍详细的催化模型，并强调这些实用且温和方法所提供的合成应用，涵盖了 2010 年至 2021 年的研究概况。
