Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
School of Life Sciences, Jiangsu Normal University, Xuzhou 221116, China.
Molecules. 2022 May 19;27(10):3270. doi: 10.3390/molecules27103270.
Seven new coumarinolignans, walthindicins A-F (, , -, ), along with five known analogs (, -), were isolated from the roots of . The structures of the new compounds are determined by detailed nuclear magnetic resonance (NMR), circular dichroism (CD) with extensive computational support, and mass spectroscopic data interpretation. Compounds were tested for their antioxidant activity in Human Cervical Cancer cells (HeLa cells). Compounds and showed higher reactive oxygen species (ROS) inhibitory activity at 20 μg/mL when compared with other natural compound-based antioxidants such as ascorbic acid. Considering the role of ROS in nuclear-factor kappa B (NF-κB) activation, compounds and were evaluated for NF-κB inhibitory activity and showed a concentration-dependent inhibition in Human Embryonic Kidney 293 cells (Luc-HEK-293).
从 中分离得到了 7 种新的香豆素木脂素，即 walthindicins A-F (,, -, )，以及 5 种已知类似物（, -）。新化合物的结构通过详细的核磁共振（NMR）、圆二色性（CD）和广泛的计算支持以及质谱数据解释来确定。对这些化合物在人宫颈癌细胞（HeLa 细胞）中的抗氧化活性进行了测试。与其他天然化合物抗氧化剂（如抗坏血酸）相比，在 20μg/mL 时，化合物 和 对活性氧（ROS）的抑制活性更高。考虑到 ROS 在核因子 kappa B (NF-κB)激活中的作用，对化合物 和 进行了 NF-κB 抑制活性评估，并在人胚肾 293 细胞（Luc-HEK-293）中显示出浓度依赖性抑制。
