2018年莫桑比克马普托肠道病毒的环境监测

Environmental Monitoring for Enteroviruses in Maputo, Mozambique-2018.

作者信息

Bero Diocreciano Matias, Nhassengo Sheila António, Sousa Ivanildo Pedro, de Sousa Silas Oliveira, Machado Raiana Scerni, Dias Amanda Meireles Nunes, de Sousa Ferreira Cristiane, Burlandy Fernanda Marcicano, de Deus Nilsa, da Silva Edson Elias

机构信息

Instituto Nacional de Saúde, Bairro da Vila de Marracuene, EN1, Parcela No 3943, Maputo P.O. Box 264, Mozambique.

Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro CEP 21040-210, Brazil.

出版信息

Pathogens. 2022 Apr 29;11(5):527. doi: 10.3390/pathogens11050527.

DOI:10.3390/pathogens11050527

PMID:35631048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9147478/

Abstract

Due to the possibility of wild poliovirus importation from endemic regions and the high circulation of vaccine-derived poliovirus type 2 in the African region, Mozambique implemented a surveillance program to monitor the circulation of enteroviruses in the environment. From January to November 2018, a period that immediately preceded the cVDPV outbreak in Africa, 63 wastewater samples were collected from different areas in Maputo city. A total of 25 samples (39.7%) were positive based on cell culture isolation. Non-polio enteroviruses were found in 24 samples (24/25; 96%), whereas 1 Sabin-related poliovirus was isolated. Neither wild nor vaccine-derived poliovirus was detected. High circulation of EVB species was detected. Environmental surveillance in the One Health approach, if effectively applied as support to acute flaccid paralysis, can be a powerful aid to the public health system to monitor poliovirus besides non-polio enteroviruses in polio-free areas.

摘要

由于存在从流行地区输入野生脊髓灰质炎病毒的可能性，以及2型疫苗衍生脊髓灰质炎病毒在非洲地区的高传播率，莫桑比克实施了一项监测计划，以监测环境中肠道病毒的传播情况。在2018年1月至11月期间，即非洲循环疫苗衍生脊髓灰质炎病毒（cVDPV）疫情爆发前夕，从马普托市不同地区采集了63份废水样本。基于细胞培养分离，共有25份样本（39.7%）呈阳性。在24份样本（24/25；96%）中发现了非脊髓灰质炎肠道病毒，同时分离出1株与萨宾相关的脊髓灰质炎病毒。未检测到野生或疫苗衍生脊髓灰质炎病毒。检测到肠道病毒B型的高传播率。在无脊髓灰质炎地区，以“同一健康”方法进行的环境监测，如果有效地作为对急性弛缓性麻痹的支持措施加以应用，可为公共卫生系统监测脊髓灰质炎病毒以及非脊髓灰质炎肠道病毒提供有力帮助。