Borba H R, Vieira Lopes L C, Silveira O, Campello A P, Kluppel M L
Res Commun Chem Pathol Pharmacol. 1987 Jan;55(1):59-65.
The effect of antiarrhythmic drugs (propranolol, lidoflazine, perhexiline maleate and iproveratril) on Ca2+ uptake and Na+-induced Ca2+ release by isolated rat heart mitochondria has been studied using arsenazo III as Ca2+ indicator. It was concluded that those drugs are not selective inhibitors either for Na+-induced Ca2+ release or for Ca2+ uptake. It seems possible that those drugs act by complexation with some components of the membrane, presumably with phospholipids.
利用偶氮胂III作为钙离子指示剂，研究了抗心律失常药物（普萘洛尔、利多氟嗪、马来酸哌克昔林和维拉帕米）对离体大鼠心脏线粒体摄取钙离子以及钠离子诱导的钙离子释放的影响。得出的结论是，这些药物既不是钠离子诱导的钙离子释放的选择性抑制剂，也不是钙离子摄取的选择性抑制剂。这些药物似乎有可能通过与膜的某些成分（可能是磷脂）络合而起作用。
