Károly Rácz Doctoral School of Clinical Medicine, Semmelweis University, Üllői Street 26, H-1085 Budapest, Hungary.
Department of Obstetrics and Gynecology, Semmelweis University, Üllői Street 78/a, H-1082 Budapest, Hungary.
Nutrients. 2022 May 13;14(10):2041. doi: 10.3390/nu14102041.
The aim of our study was to identify whether vitamin-D deficiency (VDD) can alter the geometry of the coronary-resistance-artery system. Male Wistar rats were divided into vitamin-D-deficient (VD-, n = 10) and vitamin-D-supplemented (VD+, n = 8) groups. After eight weeks, branches and segments of the left-anterior-descending-coronary-artery (LAD) network were analyzed by a video-microscopy technique. Segments were divided into 50 μm-long cylindrical ring units. VDD did not increase the number of morphological abnormalities. The number of segments did not differ between the groups (VD-: 210 and VD+: 224; pooled data of 8 networks). A larger lumen area of branches was found in VD+ group, while 1-4-order branches were lengthier in the VD- group. VD- rats had less rich coronary-resistance-artery networks in terms of 50 µm-long units. (VD-: 6365 vs. VD+: 6602; pooled data of 8 networks). VD+ animals were richer in the 100-350 µm outer diameter range, and VD- animals were richer in the 400-550 µm-diameter units. In VD- rats, 150-200 and 300 µm units were almost missing at higher flow distances from the orifice. Serum vitamin-D alterations caused by dietary changes can affect the geometry of the coronary-artery network, which may contribute to vitamin-D-dependent changes in cardiovascular mortality.
我们研究的目的是确定维生素 D 缺乏症（VDD）是否会改变冠状动脉阻力动脉系统的几何形状。雄性 Wistar 大鼠被分为维生素 D 缺乏组（VD-，n = 10）和维生素 D 补充组（VD+，n = 8）。八周后，采用视频显微镜技术分析左前降支冠状动脉（LAD）网络的分支和节段。将节段分为 50μm 长的圆柱形环单位。VDD 并未增加形态异常的数量。两组间节段数量无差异（VD-：210 个，VD+：224 个；8 个网络的汇总数据）。VD+组分支的管腔面积较大，而 VD-组 1-4 级分支较长。VD-大鼠在 50μm 长的单位中，冠状动脉阻力动脉网络较少。（VD-：6365 对 VD+：6602；8 个网络的汇总数据）。VD+动物在 100-350μm 外径范围内更丰富，VD-动物在 400-550μm 直径单位中更丰富。在 VD-大鼠中，150-200μm 和 300μm 单位在离开口更远的较高血流距离处几乎缺失。饮食变化引起的血清维生素 D 改变可能会影响冠状动脉网络的几何形状，这可能导致与维生素 D 相关的心血管死亡率变化。
