Silva Patrícia M A, Bousbaa Hassan
UNIPRO-Oral Pathology and Rehabilitation Research Unit, University Institute of Health Sciences (IUCS), University Polytechnic Higher Education Cooperative (CESPU), Rua Central de Gandra, 4585-116 Gandra, Portugal.
TOXRUN-Toxicology Research Unit, University Institute of Health Sciences (IUCS), University Polytechnic Higher Education Cooperative (CESPU), Rua Central de Gandra, 4585-116 Gandra, Portugal.
Pharmaceutics. 2022 May 18;14(5):1084. doi: 10.3390/pharmaceutics14051084.
The BUB3 protein plays a key role in the activation of the spindle assembly checkpoint (SAC), a ubiquitous surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis and, consequently, prevents chromosome mis-segregation and aneuploidy. Besides its role in SAC signaling, BUB3 regulates chromosome attachment to the spindle microtubules. It is also involved in telomere replication and maintenance. Deficiency of the BUB3 gene has been closely linked to premature aging. Upregulation of the BUB3 gene has been found in a variety of human cancers and is associated with poor prognoses. Here, we review the structure and functions of BUB3 in mitosis, its expression in cancer and association with survival prognoses, and its potential as an anticancer target.
BUB3蛋白在纺锤体组装检查点（SAC）的激活中起关键作用，SAC是一种普遍存在的监测机制，可确保有丝分裂中染色体分离的准确性，从而防止染色体错误分离和非整倍体形成。除了在SAC信号传导中的作用外，BUB3还调节染色体与纺锤体微管的附着。它还参与端粒复制和维持。BUB3基因的缺陷与早衰密切相关。在多种人类癌症中发现了BUB3基因的上调，并且与不良预后相关。在这里，我们综述了BUB3在有丝分裂中的结构和功能、其在癌症中的表达及其与生存预后的关系，以及其作为抗癌靶点的潜力。
