Paun Maria-Alexandra, Paun Vladimir-Alexandru, Paun Viorel-Puiu
School of Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.
Division Radio Monitoring and Equipment, Section Market Access and Conformity, Federal Office of Communications OFCOM, 2501 Bienne, Switzerland.
Polymers (Basel). 2022 May 20;14(10):2090. doi: 10.3390/polym14102090.
In this paper, the charged polymer escapement phenomenon, via a little hole of nano-metric dimensions arranged in a constitutive biological membrane, is studied. We will present the case of the transport process of an ideal polymer in a 3-dimensional extended region separated by a fine boundary named membrane in a free energy barrier attendance. Additionally, the general translocation time formula, respectively, the transition time from the cis area to the trans area, is presented. The model for estimation of the likelihood, designated by (, ), as a macromolecular chain of lengthiness equal to , to be able to pass by the nanopore in escape period , was optimized. The longest-lasting likely escape time found with this model is indicated to be = 330 μs. Thus, the results obtained with the described formula are in good agreement with those announced in the specialized literature.
本文研究了带电聚合物通过构成生物膜中纳米尺寸小孔的逸出现象。我们将呈现理想聚合物在由名为膜的精细边界分隔的三维扩展区域中的输运过程，该区域存在自由能垒。此外，还给出了一般的转运时间公式，即从顺式区域到反式区域的过渡时间。对用于估计长度等于 的大分子链在逃逸期 能够通过纳米孔的可能性的模型（由(, )表示）进行了优化。用该模型发现的最长可能逃逸时间为 = 330 μs。因此，用所述公式获得的结果与专业文献中公布的结果吻合良好。
