Herrera Crystal M, Schmitt Jessicia S, Chowdhry Erum I, Riddle Mark S
Reno School of Medicine, University of Nevada, Reno, NV 89557, USA.
Vaccines (Basel). 2022 Apr 20;10(5):645. doi: 10.3390/vaccines10050645.
We are at an exciting moment in time with the advancement of many vaccines, including a shigella vaccine for the world. It is instructive to look at the long road that some vaccines have traveled to recognize the remarkable accomplishments of those who were pioneers, appreciate the evolution of scientific and applied technology, and inform the future history of a vaccine that would have great potential for global health. To achieve this valuable retrospective, a narrative historical literature review was undertaken utilizing PubMed and Embase databases with relevant search terms. Retrieved articles were reviewed and information was organized into historical themes, landmark discoveries, and important vaccine development parallels. The literature reviewed was synthesized into major eras of shigella vaccine development from pathogen discovery and first attempts to empirical approaches of killed whole-cell and live-attenuated approaches, and a modern era that applied recombinant DNA engineering and structural vaccinology. The history of shigella vaccine development has largely followed the evolutionary path of vaccine development over the last 120 years, but with important lessons learned that should be considered as we embark on the future chapters of bringing to the world a safe and effective vaccine for global health.
随着包括全球通用的志贺氏菌疫苗在内的多种疫苗取得进展，我们正处于一个激动人心的时刻。回顾一些疫苗走过的漫长道路，有助于我们认识先驱者的卓越成就，了解科学与应用技术的发展历程，并为一种对全球健康具有巨大潜力的疫苗书写未来的历史。为了实现这一有价值的回顾，我们利用PubMed和Embase数据库，使用相关检索词进行了叙述性历史文献综述。对检索到的文章进行了审查，并将信息整理成历史主题、里程碑式发现以及重要的疫苗开发对比。所审查的文献被综合成志贺氏菌疫苗开发的主要时代，从病原体发现和首次尝试到灭活全细胞和减毒活疫苗的经验方法，再到应用重组DNA工程和结构疫苗学的现代时代。志贺氏菌疫苗的发展历程在很大程度上遵循了过去120年疫苗发展的演进路径，但也有一些重要的经验教训，在我们开启为全球健康带来一种安全有效疫苗的未来篇章时应予以考虑。
