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志贺洁博士(1871 - 1957):发现痢疾杆菌并为日本公共卫生事业做出巨大贡献的杰出细菌学家。

Dr. Kiyoshi Shiga (1871-1957): Outstanding Bacteriologist Who Discovered Dysentery Bacillus and Contributed Immensely to Public Health in Japan.

作者信息

Okui Nobuo

机构信息

Urogynecology, Yokosuka Urogynecology and Urology Clinic, Kanagawa, JPN.

Dentistry, Kanagawa Dental University, Kanagawa, JPN.

出版信息

Cureus. 2024 Oct 19;16(10):e71881. doi: 10.7759/cureus.71881. eCollection 2024 Oct.

Abstract

Kiyoshi Shiga (1871-1957) was a renowned Japanese bacteriologist best known for discovering the dysentery bacillus. Born in Sendai during the Meiji Restoration, Shiga graduated from Tokyo Imperial University's School (later University of Tokyo) of Medicine and began microbiological research under Shibasaburo Kitasato. In 1897, during a dysentery () epidemic, he isolated and identified the causative organism (later named ) using Koch's postulates, laying the foundation for enteric disease research. Shiga later worked with Paul Ehrlich in Germany, pioneering chemotherapy research for trypanosomiasis. Upon returning to Japan, he continued studying infectious diseases such as tuberculosis and beriberi, significantly contributing to public health improvements. As a professor at Keio University School of Medicine, Shiga advanced medical education in Japan and abroad. In his later years, he returned to his hometown near Sendai, living in harmony with nature. His gentle demeanor and scientific achievements earned him deep respect and affection from the local community. Shiga's funeral was marked by a long line of mourners, a testament to the impact he had on those around him. His life embodied the balance between scientific inquiry and humanitarian spirit, profoundly influencing the development of bacteriology and public health globally.

摘要

志贺洁(1871 - 1957)是一位著名的日本细菌学家,以发现痢疾杆菌而闻名。志贺在明治维新时期出生于仙台,毕业于东京帝国大学医学院(后为东京大学),并在北里柴三郎的指导下开始微生物学研究。1897年,在一场痢疾疫情期间,他运用科赫法则分离并鉴定出了致病生物体(后来被命名为 ),为肠道疾病研究奠定了基础。志贺后来在德国与保罗·埃利希合作,开创了针对锥虫病的化疗研究。回到日本后,他继续研究结核病和脚气病等传染病,为公共卫生的改善做出了重大贡献。作为庆应义塾大学医学院的教授,志贺推动了日本国内外的医学教育发展。在晚年,他回到仙台附近的家乡,与自然和谐相处。他温和的举止和科学成就赢得了当地社区的深深尊敬和爱戴。志贺的葬礼上有长长的哀悼队伍,这证明了他对周围人的影响。他的一生体现了科学探索与人道主义精神之间的平衡,对全球细菌学和公共卫生的发展产生了深远影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7f0/11573232/2f901986369d/cureus-0016-00000071881-i01.jpg

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